163768-51-2

Basic information

• Product Name: (S)-tert-butyl 2-((1R,2R)-3-(benzyloxy)-1-hydroxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate
• Synonyms: (S)-tert-butyl 2-((1R,2R)-3-(benzyloxy)-1-hydroxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate
• CAS NO: 163768-51-2
• Molecular Weight: 363.454
• Mol File: 163768-51-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-tert-butyl 2-((1R,2R)-3-(benzyloxy)-1-hydroxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-tert-butyl 2-((1R,2R)-3-(benzyloxy)-1-hydroxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate(163768-51-2)
• EPA Substance Registry System: (S)-tert-butyl 2-((1R,2R)-3-(benzyloxy)-1-hydroxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate(163768-51-2)

Safety Data

• Hazardous Substances Data: 163768-51-2(Hazardous Substances Data)

Usage

General Description

The chemical (S)-tert-butyl 2-((1R,2R)-3-(benzyloxy)-1-hydroxy-2-methyl-3-oxopropyl)pyrrolidine-1-carboxylate, also known as tert-butyl 2-((1R,2R)-3-(benzyloxy)-1-hydroxy-2-methyl-3-oxo-1-propyl)pyrrolidine-1-carboxylate, is a pyrrolidine derivative. It consists of a pyrrolidine ring with a tert-butyl ester group and a hydroxy-methyl-oxo-propyl substituent. This chemical compound is commonly used as a building block in the synthesis of various pharmaceutical drugs and organic compounds. It is essential in the production of active ingredients in many medications and plays a crucial role in drug discovery and development processes.

Upstream product

• 122-63-4 benzyl proprionate 
• 69610-41-9 Boc-L-Pro-H 

Downstream Products

• 149606-97-3 benzyl (2R,3R,2'S)-3-(N-tert-butoxycarbonyl-2'-pyrrolidinyl)-3-methoxy-2-methylpropanoate 
• 173441-07-1 (S)-2-[(1R,2R)-2-Benzyloxycarbonyl-1-(imidazole-1-carbothioyloxy)-propyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 130272-98-9 (S)-N-{(S)-1-[((1S,2S)-1-((S)-sec-Butyl)-2-methoxy-4-{(S)-2-[(1R,2R)-1-methoxy-2-((S)-2-phenyl-1-thiazol-2-yl-ethylcarbamoyl)-propyl]-pyrrolidin-1-yl}-4-oxo-butyl)-methyl-carbamoyl]-2-methyl-propyl}-2-dimethylamino-3-methyl-butyramide 
• 120205-50-7 N-Boc-(2R,3R,4S)-dolaproine 
• 120205-54-1 tert-butyl (2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}propyl]pyrrolidine-1-carboxylate 
• 110417-88-4 dolastatin 10 
• 148565-06-4 Boc-(2R,3R,4S)-norDap-(S)-Doe 
• 173441-06-0 benzyl (2R,2'S)-3-(N-tert-butoxycarbonyl-2'-pyrrolidinyl)-2-methylpropanoate 
• 1026553-29-6 (R)-2-Methyl-N-((S)-2-phenyl-1-thiazol-2-yl-ethyl)-3-(S)-pyrrolidin-2-yl-propionamide 
• 173441-19-5 (S)-2-[(R)-2-((S)-2-Phenyl-1-thiazol-2-yl-ethylcarbamoyl)-propyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Synthesis and antitumor activity of novel dolastatin 10 analogs

Dolastatin 10 (1) is a potent antineoplastic pentapeptide. Novel dolastatin 10 analogs each modified at one of the constituent amino acid derivatives, were synthesized and their antitumor activity was evaluated against P388 leukemia in mice. The structural requirements for antitumor activity are discussed. Some of the analogs, 31c, 35c, 38b, and 50c showed excellent activity in vivo. Highly active 50c, which lacks the thiazole group of 1, was selected for further development as an antitumor agent.