1637735-84-2

Basic information

• Product Name: FIIN-3
• Synonyms: FIIN-3;FIN-3
• CAS NO: 1637735-84-2
• Molecular Formula: C34H36Cl2N8O4
• Molecular Weight: 691.60684
• Mol File: 1637735-84-2.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 909.4±65.0 °C(Predicted)
• Appearance: /
• Density: 1.379±0.06 g/cm3(Predicted)
• PKA: 10.78±0.70(Predicted)
• CAS DataBase Reference: FIIN-3(CAS DataBase Reference)
• NIST Chemistry Reference: FIIN-3(1637735-84-2)
• EPA Substance Registry System: FIIN-3(1637735-84-2)

Safety Data

• Hazardous Substances Data: 1637735-84-2(Hazardous Substances Data)

Usage

Description

FIIN-3 is an inhibitor of FGF receptors (FGFRs; IC50s = 13, 21, 31, and 35 nM for recombinant FGFR1-4, respectively). It is selective for FGFRs over a panel of 456 kinases at a concentration of 1 μM, however, it does inhibit EGFR (IC50 = 204 nM). FIIN-3 inhibits growth of Ba/F3 cells that are dependent on the kinase activity of wild-type FGFR1-4 as well as gatekeeper mutant FGFR2 and FGFR3 (EC50s = <1-69 nM) and inhibits FGFR-dependent signaling in a concentration-dependent manner in FGFR2TEL/V564M-dependent Ba/F3 cells. FIIN-3 also inhibits growth in a panel of cancer cell lines (EC50s = 1.4-499 nM).

Uses

FIIN-?3 is FGFR inhibitor. It can be used in synthetic preparation and complex with EGFR kinase of crystal structure; development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors.