1638-41-1 Usage
Description
PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]is a cell-permeable symmetrical sulfone compound that acts as a potent and ATP-competitive inhibitor of p38α/β MAPK (IC50 = 130 and 550 nM, respectively). It exhibits much reduced activity against p38γ/δ, ERK1/2, and JNK1/2/3. PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]has been shown to be more effective than SB 203850 in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 μM respective inhibitor).
Uses
Used in Pharmaceutical Industry:
PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]is used as a p38 MAP Kinase Inhibitor IV for blocking p38α kinase activation. This is done in order to examine if HOXB7 is involved in the regulation of migration and proliferation processes via AKT/MAPK signaling.
Used in Research Applications:
PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]is used as a research tool for studying the role of p38α/β MAPK in various cellular processes and diseases. Its potent and selective inhibition of p38α/β MAPK makes it a valuable compound for understanding the underlying mechanisms and potential therapeutic targets in conditions where p38α/β MAPK is implicated.
Biochem/physiol Actions
p38 MAP Kinase Inhibitor IV is an ATP-competitive inhibitor of p38α/β MAPK with IC50 values of 130 nM for p38α and 550 nM for p38β. It is much less active with ≤23% inhibition at 1 μM against p38γ/σ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203580 in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 μM inhibitor). A recent study showed that p38 MAP Kinase Inhibitor IV could consistently and significantly enhance reprogramming and iPS cell generation from somatic cells.
Check Digit Verification of cas no
The CAS Registry Mumber 1638-41-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,3 and 8 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1638-41:
(6*1)+(5*6)+(4*3)+(3*8)+(2*4)+(1*1)=81
81 % 10 = 1
So 1638-41-1 is a valid CAS Registry Number.