16381-46-7

Basic information

• Product Name: 5-FLUORO-3-METHYL-1H-INDOLE-2-CARBOXYLIC ACID
• Synonyms: 5-FLUORO-3-METHYL-1H-INDOLE-2-CARBOXYLIC ACID;TIMTEC-BB SBB010883;5-fluoro-3-methyl-1H-indole-2-carboxylic acid(SALTDATA: FREE)
• CAS NO: 16381-46-7
• Molecular Formula: C10H8FNO2
• Molecular Weight: 193.17
• Mol File: 16381-46-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 412.8 °C at 760 mmHg
• Flash Point: 203.5 °C
• Appearance: /
• Density: 1.432 g/cm³
• Vapor Pressure: 1.49E-07mmHg at 25°C
• Refractive Index: 1.668
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 5-FLUORO-3-METHYL-1H-INDOLE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FLUORO-3-METHYL-1H-INDOLE-2-CARBOXYLIC ACID(16381-46-7)
• EPA Substance Registry System: 5-FLUORO-3-METHYL-1H-INDOLE-2-CARBOXYLIC ACID(16381-46-7)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 16381-46-7(Hazardous Substances Data)

Usage

General Description

5-Fluoro-3-methyl-1H-indole-2-carboxylic acid is a chemical compound with the molecular formula C10H8FNO2. It is a derivative of indole and belongs to the class of carboxylic acids. 5-FLUORO-3-METHYL-1H-INDOLE-2-CARBOXYLIC ACID contains a fluorine atom, a methyl group, and a carboxylic acid group attached to the indole ring. It is commonly used as a building block in the synthesis of pharmaceuticals and other organic compounds. This chemical has potential applications in the fields of medicinal chemistry, drug design, and drug discovery due to its structural features and reactivity. Additionally, it may be used as a reagent or intermediate in organic synthesis for the preparation of various complex molecules.

InChI:InChI=1/C10H8FNO2/c1-5-7-4-6(11)2-3-8(7)12-9(5)10(13)14/h2-4,12H,1H3,(H,13,14)

Upstream product

• 16382-19-7 ethyl 5-fluoro-3-methyl-1H-indole-2-carboxylate 

Downstream Products

• 392-13-2 5-fluoro-3-methyl-1H-indole 

Relevant articles and documents

Mutational biosynthesis to generate novel analogs of nosiheptide featuring a fluorinated indolic acid moiety

Nosiheptide (NOS) is a member of bicyclic thiopeptides possessing a biologically important indolic acid (IA) moiety appended onto the family-characteristic core system. The IA formation relies primarily on NosL, a radical S-adenosylmethionine (SAM) protein that catalyzes a complex rearrangement of the carbon side chain ofl-tryptophan, leading to the generation of 3-methyl-2-indolic acid (MIA). Here, we establish an efficient mutational biosynthesis strategy for the structural expansion of the side-ring system of NOS. ThenosL-deficient mutantStreptomyces actuosusSL4005 complemented by chemically feeding 6-fluoro-MIA is capable of accumulating two new products. The target product 6′-fluoro-NOS contains an additional fluorine atom at C6 of the IA moiety, in contrast with an unexpected product 6′-fluoro-NOSint that features an open side ring and a bis-dehydroalanine (Dha) tail. The newly obtained 6′-fluoro-NOS displayed equivalent or slightly reduced activities against the tested drug-resistant pathogens compared with NOS, but dramatically decreased water solubility compared with NOS. Our results indicate that the modification of the IA moiety of NOS not only affects its biological activity but also affects its activity which will be key considerations for further modification.

Phenylaminopropanol derivatives and methods of their use

The present invention is directed to phenylaminopropanol derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.