1638138-12-1

Basic information

• Product Name: ((R)-2,2-cyclohexylidine-1,3-dioxolan-4-yl)methyl 4-methylbenzenesulphonate
• Synonyms: ((R)-2,2-cyclohexylidine-1,3-dioxolan-4-yl)methyl 4-methylbenzenesulphonate
• CAS NO: 1638138-12-1
• Molecular Weight: 326.414
• Mol File: 1638138-12-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ((R)-2,2-cyclohexylidine-1,3-dioxolan-4-yl)methyl 4-methylbenzenesulphonate(CAS DataBase Reference)
• NIST Chemistry Reference: ((R)-2,2-cyclohexylidine-1,3-dioxolan-4-yl)methyl 4-methylbenzenesulphonate(1638138-12-1)
• EPA Substance Registry System: ((R)-2,2-cyclohexylidine-1,3-dioxolan-4-yl)methyl 4-methylbenzenesulphonate(1638138-12-1)

Safety Data

• Hazardous Substances Data: 1638138-12-1(Hazardous Substances Data)

Upstream product

• 108-94-1 cyclohexanone 
• 95335-91-4 (S)-1,4-dioxaspiro<4.5>decane-2-methanol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 41274-09-3 (R)-3-tosyloxy-1,2-propanediol 

Relevant articles and documents

Enantiodivergent syntheses of (+)- and (?)-1-(2,6-dimethylphenoxy)propan-2-ol: A way to access (+)- and (?)-mexiletine from D-(+)-mannitol

Chiron approach was used to acquire optically pure (R)- and (S)-1-(2,6-dimethylphenoxy)propan-2-ol, immediate precursors of (S)- and (R)-mexiletines, respectively. Two different routes were followed from a D-mannitol-derived optically pure common precursor to get the enantiomeric alcohols separately. Comparison of their specific rotation values with the corresponding literature values as well as exact mirror-image relationship between their CD curves proved their high enantiopurity. These alcohols were then transformed to the corresponding amine-drugs in an efficient one-step process instead of two steps described in the literature.