1638147-93-9

Upstream product

• 182316-01-4 (5R)-5,6-dihydro-5-phenyl-2H-1,4-oxazin-2-one-N-oxide 
• 534-22-5 2-methylfuran 
• 1638147-89-3 (3R,5R)-4-hydroxy-3-(5-methylfuran-2-yl)-5-phenylmorpholin-2-one 

Relevant academic research and scientific papers

Concise preparation of optically active heteroaryl α-(hydroxyamino) esters

A practical sequence for the synthesis of optically active heteroaryl α-(hydroxyamino) esters was explored. The highly diastereoselective addition of heteroaromatics to a cyclic chiral nitrone allowed access to a series of heteroaryl hydroxylamines. The scope of this reaction was evaluated on substrates possessing a pyrrole, an indole, or a furan core. The three-step sequence afforded the α-(hydroxyamino) esters in good overall yields (36-62-%) with good enantiomeric excess values (76 to ≥98-%). The highly diastereoselective addition of heteroaromatics to a cyclic chiral nitrone allows access to a series of heteroaryl hydroxylamines. The scope of this reaction is presented on substrates possessing a pyrrole, an indole, or a furan core. The three-step sequence affords α-(hydroxyamino) esters in good overall yields (36-62-%) with good enantiomeric excess values (76 to ≥98-%). Copyright