1638152-60-9Relevant academic research and scientific papers
Palladium-catalyzed decarboxylative cycloaddition of vinylethylene carbonates with formaldehyde: Enantioselective construction of tertiary vinylglycols
Khan, Ajmal,Zheng, Renfeng,Kan, Yuhe,Ye, Jiang,Xing, Juxiang,Zhang, Yong Jian
, p. 6439 - 6442 (2014/06/24)
An efficient method for the enantioselective construction of tertiary vinylglycols through a palladium-catalyzed asymmetric decarboxylative cycloaddition of vinylethylene carbonates with formaldehyde was developed. By using a palladium complex generated in situ from [Pd2(dba) 3]·CHCl3 and a phosphoramidite ligand as a catalyst under mild reaction conditions, the process allows conversion of racemic 4-substituted 4-vinyl-1,3-dioxolan-2-ones into the corresponding 1,3-dioxolanes, as methylene acetal protected tertiary vinylglycols, in high yields with good to excellent enantioselectivities.
