1638156-47-4Relevant articles and documents
Transition-metal-free approach to 4-ethynylpyrimidines via alkenynones
Golubev, Pavel R.,Pankova, Alena S.,Kuznetsov, Mikhail A.
, p. 3614 - 3621 (2014/06/23)
A practical approach to the synthesis of 4-ethynylpyrimidines by the condensation of arylamidines with 2-aryl-1-ethoxy-5-(trimethylsilyl)pent-1-en-4- yn-3-ones has been developed. As these latter ketones are easily accessible from bis(trimethylsilyl)acetylene and arylacetyl chlorides, the regioselective condensation reported herein provides a facile access to both TMS-protected and unprotected 4-ethynylpyrimidines in yields of up to 85%. Copyright