1638159-47-3

Basic information

• Product Name: 3-(2,4-dichloro-6-fluorophenyl)quinoline
• Synonyms: 3-(2,4-dichloro-6-fluorophenyl)quinoline
• CAS NO: 1638159-47-3
• Molecular Weight: 275.685
• Mol File: 1638159-47-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(2,4-dichloro-6-fluorophenyl)quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2,4-dichloro-6-fluorophenyl)quinoline(1638159-47-3)
• EPA Substance Registry System: 3-(2,4-dichloro-6-fluorophenyl)quinoline(1638159-47-3)

Safety Data

• Hazardous Substances Data: 1638159-47-3(Hazardous Substances Data)

Upstream product

• 5332-24-1 3-bromoquinoline 
• 1435-43-4 1-chloro-3,5-difluorobenzene 

Relevant articles and documents

Reactivity of 3-substituted fluorobenzenes in palladium-catalysed direct arylations with aryl bromides

The influence of both electron-withdrawing and electron-donating substituents such as nitro, nitrile, chloro, bromo and methoxy at C-3 on fluorobenzenes for their palladium-catalysed direct C-2 arylation has been explored. With electron-withdrawing substituents, the reaction proceeds nicely using 2-4 mol% of an air-stable palladium complex and potassium pivalate/dimethylacetamide (PivOK/DMA) as catalytic system; and in general, a very regioselective arylation at C-2 was observed. Moreover, a variety of substituents on the aryl bromide coupling partner, such as benzoyl, formyl, nitro, nitrile, chloro and methyl, and also heteroaryl bromides were tolerated.