1638220-75-3

Upstream product

• 35660-94-7 (E)-2-methylbut-2-enoyl chloride 
• 1492056-85-5 (S)-tert-butyl 3-((R)-4-isopropyl-2-oxooxazolidine-3-carbonyl)-3-methylpent-4-enoate 
• 1492056-88-8 (S)-tert-butyl 3-(hydroxymethyl)-3-methylpent-4-enoate 
• 1492056-89-9 (S)-tert-butyl 3-(((tert-butyldimethylsilyl)oxy)methyl)-3-methylpent-4-enoate 
• 1638217-25-0 (R)-3-(((tert-butyldimethylsilyl)oxy)methyl)-3-methylpentan-1-ol 
• 1638220-66-2 (R)-3-(((tert-butyldimethylsilyl)oxy)methyl)-3-methylpentanal 
• 1492056-91-3 (S,E)-ethyl 5-(((tert-butyldimethylsilyl)oxy)methyl)-5-methylhepta-2,6-dienoate 
• 1638220-67-3 (R,E)-ethyl 5-(((tert-butyldimethylsilyl)oxy)methyl)-5-methylhept-2-enoate 
• 1492056-92-4 (S,E)-ethyl 5-(hydroxymethyl)-5-methylhepta-2,6-dienoate 
• 1638220-68-4 (R,E)-ethyl 5-(hydroxymethyl)-5-methylhept-2-enoate 
• 1492056-94-6 (S,E)-ethyl 5-formyl-5-methylhepta-2,6-dienoate 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 1492056-95-7 (S,2E,6E)-ethyl 7-iodo-5-methyl-5-vinylhepta-2,6-dienoate 

Downstream Products

• 1638220-82-2 (S,3E,7E)-2,6-dimethyl-8-(4-(trifluoromethyl)phenyl)-6-vinylocta-3,7-dien-2-ol 

Relevant academic research and scientific papers

Δ3 Asymmetric synthesis method -2 - hydroxyl psoralen and analogue compound

The invention belongs to the field of chemical synthesis, provides a novel method for synthesizing delta3-2-hydroxybakuchiol and particularly relates to an asymmetric synthesis method for delta3-2-hydroxybakuchiol and analog compounds. The delta3-2-hydroxybakuchiol and the analog compounds, the general formula of which is (I), are synthesized by an asymmetric synthesis route. Problems in the prior art, that the content of the delta3-2-hydroxybakuchiol obtained by extraction and separation from plants is very low, an extraction rate is very low, the delta3-2-hydroxybakuchiol is prone to oxidative deterioration in extraction and separation processes, and the like, are overcome by the method. The method can provide sufficient samples for related pharmaceutical research, and provides good foundations for pharmaceutical research on antibiosis, infection resistance, oxidation resistance, pigment deposition resistance, reduction of bone loss, immunosuppression, liver damage, sedation and hypnosis, and the like. In the formula (I), R1 is selected from 4-hydroxy, 3-hydroxy, 2-hydroxy, hydrogen, 4-methyl, 4-methoxy, 4-trifluoromethyl, 3,4-[d][1,3]dioxole, and 3,4-phenyl; R2 is selected from methyl, ethyl, and butyl; and R3 is selected from vinyl, ethyl and cyclopropyl.

Synthesis of Δ3-2-hydroxybakuchiol analogues and their growth inhibitory activity against rat UMR106 cells

A series of Δ3-2-hydroxybakuchiol analogues have been synthesized and tested for their growth inhibitory activity against rat UMR106 cells by using the MTT method. Some of them exhibit enhanced activities compared with the natural product, and the preliminary SAR profile shows that the chain tail on the natural product could be subtly modified to enhance the activity and the aromatic moiety or the terminal olefin on the main chain can also be modified without any evident loss of activity. The stereo-configuration of the quaternary chiral center has an important influence on the activity.