1638642-76-8Relevant academic research and scientific papers
Organocatalytic oxidative annulation of benzamide derivatives with alkynes
Manna, Srimanta,Antonchick, Andrey P.
supporting information, p. 7324 - 7327 (2014/07/21)
Organocatalytic annulation by functionalization of benzamide derivatives with alkynes has been developed. We report a new approach of cycloaddition under mild reaction conditions using simple catalysts, such as iodobenzene and peracetic acid, as oxidant. Those novel, mild reaction conditions provided a straightforward synthesis of isoquinolones with fast reaction rate. Notable selectivity in annulation of unsymmetrically disubstituted alkynes was demonstrated.
