1638677-65-2Relevant academic research and scientific papers
Formation of four different aromatic scaffolds from nitriles through tandem divergent catalysis
Kim, Ju Hyun,Bouffard, Jean,Lee, Sang-Gi
supporting information, p. 6435 - 6438 (2014/06/24)
A zinc bromide complex, formed by the sequential reaction of nitriles with a Reformatsky reagent and terminal alkynes, is used as an intermediate for divergent palladium-catalyzed reactions. The reaction pathway of the intermediate is precisely controlled by the choice of the reaction solvent or the palladium catalyst to quickly form four different aromatic scaffolds - arylamines, aminoindenes, pyrroles, and quinolines - starting from readily available nitriles.
