163886-93-9

Basic information

• Product Name: 3-(5-bromo-1H-indol-3-yl)-N-methylsuccinimide
• Synonyms: 3-(5-bromo-1H-indol-3-yl)-N-methylsuccinimide
• CAS NO: 163886-93-9
• Molecular Formula: C13H11BrN2O2
• Molecular Weight: 307
• Mol File: 163886-93-9.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(5-bromo-1H-indol-3-yl)-N-methylsuccinimide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(5-bromo-1H-indol-3-yl)-N-methylsuccinimide(163886-93-9)
• EPA Substance Registry System: 3-(5-bromo-1H-indol-3-yl)-N-methylsuccinimide(163886-93-9)

Safety Data

• Hazardous Substances Data: 163886-93-9(Hazardous Substances Data)

Upstream product

• 327602-01-7 3-(5-bromo-1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione 
• 930-88-1 N-methylmaleimide 
• 10075-50-0 5-bromo-1H-indole 

Downstream Products

• 208464-78-2 C₂₅H₂₆N₂O₂ 
• 208464-43-1 5-bromo-3-(N-methylpyrrolidin-3-yl)-1-benzoylindole 

Relevant articles and documents

Bf3-oet2 catalyzed c3-alkylation of indole: Synthesis of indolylsuccinimidesand their cytotoxicity studies

A simple and efficient BF3-OEt2 promoted C3-alkylation of indole has been developed to obtain3-indolylsuccinimidesfrom commercially available indoles and maleimides, with excellent yields under mild reaction conditions. Furthermore,

5-CYCLO INDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS

Described herein are compounds selective for a 5-HT1D-like receptor, which have general formula (I), wherein A is selected from a six-membered, non-aromatic, optionally substituted carbocycle and a six-membered, non-aromatic, optionally substituted heterocycle having one or two heteroatoms selected from O, S, SO, SO2 and NR; R is selected from H and OH; n is 0 or 1 as permitted by chemical structure; R is selected from CRRCH2NRR or a group of formula (II), (III) or (IV); R is selected from H and benzoyl; R is selected from H, loweralkyl, benzyl, loweralkylcarbonyl, loweralkylaminocarbonyl; loweralkylaminothiocarbonyl, loweralkanoyl, loweralkylaminoimide and loweralkoxy-substituted loweralkylene; R and R are independently selected from H, loweralkoxy and hydroxy; R and R are independently selected from H and loweralkyl or R and R form an alkylene bridge which, together with the nitrogen atom to which they are attached, creates an optionally substituted 3- to 6-membered ring; ----- denotes a single or double bond; and R, R and R are independently selected from H and loweralkyl. Also described is the use of these compounds as pharmaceuticals to treat indications where stimulation of a 5-HT1D-like receptor is implicated, such as migraine.

5-ALKENYL AND 5-ALKYNYL INDOLE COMPOUNDS

Described herein are compounds selective for 5-HT 1D-like receptors, which have the general formula: STR1 wherein: R 1 is selected from H, aryl and aryl substituted with 1, 2 or 3 substituents independently selected from loweralkyl, loweralkoxy, loweralkylcarbonyl, loweralkyl-S--, loweralkyl-S(O)--, loweralkyl-SO 2-, S=C=N--, O=C=N--, halo, loweralkoxycarbonyl, nitro, amino, loweralkyl-NH--, (loweralkyl) 2--N--, loweralkyl-SO 2-loweralkyl-; A is a double or triple bond;R 2 is selected from a group of Formula II, III, IV and V: STR2 R 3 is selected from H and loweralkyl; R 4 is selected from H and loweralkyl; One of R 5 and R 6 is H and the other is independently selected from H, loweralkoxy, loweralkyl and hydroxy; andR 7 and R 8 are independently selected from H and loweralkyl or R 7 and R 8, together with the nitrogen atom to which they are attached, form an optionally substituted 3-to 6-membered ring;or a salt, solvate or hydrate thereof.Also described is the use of these compounds as pharmaceuticals to treat indications where stimulation of the 5-HT 1D-like receptor is implicated, such as migraine.