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163887-48-7

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163887-48-7 Usage

General Description

The chemical "H-D-TYR-ILE-ASN-LEU-ILE-D-THR-ARG-GLN-ARG-D-TYR-NH2" is a peptide consisting of a sequence of amino acids. It begins with the amino acid tyrosine (TYR), followed by isoleucine (ILE), asparagine (ASN), leucine (LEU), isoleucine (ILE), D-threonine (D-THR), arginine (ARG), glutamine (GLN), and arginine (ARG), and ends with another tyrosine (TYR). The peptide is capped with an N-terminal acetyl group and a C-terminal amide group, denoted by "H" and "NH2" respectively. The specific sequence and arrangement of the amino acids give the peptide its unique chemical properties and potential biological activity.

Check Digit Verification of cas no

The CAS Registry Mumber 163887-48-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,3,8,8 and 7 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 163887-48:
(8*1)+(7*6)+(6*3)+(5*8)+(4*8)+(3*7)+(2*4)+(1*8)=177
177 % 10 = 7
So 163887-48-7 is a valid CAS Registry Number.

163887-48-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name H-D-TYR-ILE-ASN-LEU-ILE-D-THR-ARG-GLN-ARG-D-TYR-NH2

1.2 Other means of identification

Product number -
Other names D-TYR-ILE-ASN-LEU-ILE-D-THR-ARG-GLN-ARG-D-TYR-NH2

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:163887-48-7 SDS

163887-48-7Downstream Products

163887-48-7Relevant articles and documents

Novel Modified Carboxy Terminal Fragments of Neutropeptide Y with High Affinity for Y2-Type Receptors and Potent Functional Antagonism at a Y1-Type Receptor

Leban, Johann J.,Heyer, Dennis,Landavazo, Antonio,Matthews, Jessica,Aulabaugh, Ann,Daniels, Alejandro J.

, p. 1150 - 1157 (1995)

Peptide analogs of neuropeptide Y (NPY) with a Tyr-32 and Leu-34 replacement resulted in the decapeptide TyrIleAsnLeuIleTyrArgLeuArgTyr-NH2 (9; Table 1) and a 3700-fold improvement in affinity at Y2 (rat brain; IC50 = 8.2 +/- 3 nM) receptors when compared to the native NPY(27-36) C-terminal fragment.In addition, compound 9 was an agonist at Y1 (human erythroleukemia (HEL) cell; ED50 = 8.8 +/- 0.5 nM) receptors with potency comparable to that of NPY(1-36) (ED50 = 5 nM).Molecular dynamics and 1H-NMR were used to propose a solution structure of decapeptide 9 and for subsequent analog design.The replacement of Leu with Pro at position 4 of decapeptide 9 afforded an antagonist of NPY in HEL cells (18, TyrIleAsnProIleTyrArgLeuArgTyr-NH2; IC50 = 100 +/- 5 nM).Deletion of the N-terminal tyrosine of 18 resulted in a 10-fold improvement in antagonistic activity with a parallel 4-fold decrease in Y2 affinity.This potent antagonist may provide further insight into the physiological role(s) for NPY in the mammalian and peripheral nervous system.

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