163887-48-7 Usage
Uses
Used in Pharmaceutical Industry:
H-D-TYR-ILE-ASN-LEU-ILE-D-THR-ARG-GLN-ARG-D-TYR-NH2 is used as a pharmaceutical agent for its potential biological activity. The specific sequence of amino acids in the peptide may confer therapeutic properties, making it a candidate for the development of new drugs or treatments.
Used in Research and Development:
H-D-TYR-ILE-ASN-LEU-ILE-D-THR-ARG-GLN-ARG-D-TYR-NH2 is used as a research tool in the field of biochemistry and molecular biology. The peptide's unique sequence and properties can be studied to gain insights into the structure-function relationships of peptides and their potential applications in various biological processes.
Used in Cosmetics Industry:
H-D-TYR-ILE-ASN-LEU-ILE-D-THR-ARG-GLN-ARG-D-TYR-NH2 may be used as an ingredient in cosmetic products due to its potential biological activity. The peptide could be incorporated into skincare formulations to provide benefits such as anti-aging, skin repair, or hydration.
Used in Food Industry:
H-D-TYR-ILE-ASN-LEU-ILE-D-THR-ARG-GLN-ARG-D-TYR-NH2 could be utilized in the food industry as a functional ingredient or a bioactive component. The peptide's unique properties may contribute to the development of novel food products with enhanced nutritional or health benefits.
Check Digit Verification of cas no
The CAS Registry Mumber 163887-48-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,3,8,8 and 7 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 163887-48:
(8*1)+(7*6)+(6*3)+(5*8)+(4*8)+(3*7)+(2*4)+(1*8)=177
177 % 10 = 7
So 163887-48-7 is a valid CAS Registry Number.
163887-48-7Relevant academic research and scientific papers
Leban, Johann J.,Heyer, Dennis,Landavazo, Antonio,Matthews, Jessica,Aulabaugh, Ann,Daniels, Alejandro J.
, p. 1150 - 1157 (1995)
Peptide analogs of neuropeptide Y (NPY) with a Tyr-32 and Leu-34 replacement resulted in the decapeptide TyrIleAsnLeuIleTyrArgLeuArgTyr-NH2 (9; Table 1) and a 3700-fold improvement in affinity at Y2 (rat brain; IC50 = 8.2 +/- 3 nM) receptors when compared to the native NPY(27-36) C-terminal fragment.In addition, compound 9 was an agonist at Y1 (human erythroleukemia (HEL) cell; ED50 = 8.8 +/- 0.5 nM) receptors with potency comparable to that of NPY(1-36) (ED50 = 5 nM).Molecular dynamics and 1H-NMR were used to propose a solution structure of decapeptide 9 and for subsequent analog design.The replacement of Leu with Pro at position 4 of decapeptide 9 afforded an antagonist of NPY in HEL cells (18, TyrIleAsnProIleTyrArgLeuArgTyr-NH2; IC50 = 100 +/- 5 nM).Deletion of the N-terminal tyrosine of 18 resulted in a 10-fold improvement in antagonistic activity with a parallel 4-fold decrease in Y2 affinity.This potent antagonist may provide further insight into the physiological role(s) for NPY in the mammalian and peripheral nervous system.
