1639-35-6

Upstream product

• 50-00-0 formaldehyd 
• 506-59-2 N,N-dimethylammonium chloride 
• 118-93-4 o-hydroxyacetophenone 

Downstream Products

• 108649-56-5 4-Chloro-2-((E)-3-dimethylamino-1-[1,2,4]triazol-1-yl-propenyl)-phenol 
• 108649-56-5 4-Chloro-2-((Z)-3-dimethylamino-1-[1,2,4]triazol-1-yl-propenyl)-phenol 
• 491-37-2 2,3-dihydro-4H-1-benzopyran-4-one 
• 108649-50-9 (E)-1-<1-(2-hydroxyphenyl)-2-<(dimethylamino)methyl>vinyl>-1H-imidazole 
• 108649-51-0 (Z)-1-<1-(2-hydroxyphenyl)-2-<(dimethylamino)methyl>vinyl>-1H-imidazole 
• 444177-43-9 1-(2-hydroxyphenyl)-3-(3,5-dimethylpyrazol-1-yl)-1-propanone 
• 61998-14-9 S-(3-(2-hydroxyphenyl)-3-oxopropyl) N,N-dimethyldithiocarbamate 
• 108649-16-7 [(E)-3-Imidazol-1-yl-3-(2-isobutoxy-phenyl)-allyl]-dimethyl-amine 
• 108649-26-9 [(Z)-3-Imidazol-1-yl-3-(2-isobutoxy-phenyl)-allyl]-dimethyl-amine 
• 108649-18-9 [(E)-3-Imidazol-1-yl-3-(2-propoxy-phenyl)-allyl]-dimethyl-amine 
• 108649-52-1 (E)-1-<1-(2-hydroxyphenyl)-2-<(N-methylanilino)methyl>vinyl>-1H-imidazole 
• 108649-55-4 (Z)-1-<1-(2-hydroxyphenyl)-2-<(N-methylanilino)methyl>vinyl>-1H-imidazole 
• 108649-22-5 {(E)-3-[2-(4-Chloro-benzyloxy)-phenyl]-3-imidazol-1-yl-allyl}-dimethyl-amine 
• 108649-30-5 [(Z)-3-Imidazol-1-yl-3-(2-isobutoxy-phenyl)-allyl]-methyl-phenyl-amine 

Relevant academic research and scientific papers

Role of the X Coligands in Cyclometalated [Ni(Phbpy)X] Complexes (HPhbpy = 6-Phenyl-2,2′-bipyridine)

The coligand X was varied in the organonickel complexes [Ni(Phbpy)X] (X = F, Cl, Br, I, C6F5) carrying the anionic tridentate CNN ligand 6-(phen-2-ide)-2,2′-bipyridine (Phbpy-) to study its effect on electronic structures of these complexes and their activity in Negishi-like C-C cross-coupling catalysis. The complexes were synthesized from the precursor [Ni(COD)2] (COD = 1,5-cyclooctadiene) by chelate-assisted oxidative addition into the phenyl C-X bond of the protoligand 6-(2-halidophenyl)-2,2′-bipyridine) and were obtained as red powders. Protoligands X-Phbpy carrying the halide surrogates X = OMe, OTf (triflate) failed in this reaction. Single-crystal XRD allowed us to add the structures of [Ni(Phbpy)Cl] and [Ni(Phbpy)I] to the previously reported Br derivative. Cyclic voltammetry showed reversible reductions for X = C6F5, F, Cl, while for Br and I the reversibility is reduced through rapid splitting of X- after reduction (EC mechanism). UV-vis spectroelectrochemistry confirmed the decreasing degree of reversibility along the series C6F5 > F > Cl ? Br > I, which parallels the "leaving group character"of the X coligands. This method also revealed mainly bpy centered reduction and essentially Ni(II)/Ni(III) oxidations, as corroborated by DFT calculations. The rather X-invariant long-wavelength UV-vis absorptions and excited states were analyzed in detail using TD-DFT and were consistent with predominant metal to ligand charge transfer (MLCT) character. Initial catalytic tests under Negishi-like conditions showed the complexes to be active as catalysts in C-C cross-coupling reactions but did not display marked differences along the series from Ni-F to Ni-I.

A novel antifungal agent with broad spectrum: 1-(4-Biphenylyl)-3-(1H- imidazol-1-yl)-1-propanone

A series of (1-substituted aryl)-3-(1H-imidazol-1-yl)-1-propanones was synthesized through the N-alkylation of imidazole with 3-dimethylamino-1- (substituted aryl)-1-propanone hydrochlorides (ketonic Mannich bases). A second series of N1-substituted imidazoles was obtained by the reduction of the carbonyl function of the imidazole-ketones in the previous series by means of NaBH4. All of the compounds were evaluated for antifungal activity against 16 strains of Candida, and 3-(1H-imidazol-1-yl)-1-(4-biphenylyl)-1- propanone emerged as a broad-spectrum antifungal agent. Several 3-(1H-imidazol-1-yl)-1-(2′-(substituted benzyl)oxyphenyl)-1-propanones were also active towards Candida kefyr. Copyright

A Modified Synthesis of 4-Chromanones

Problems in the synthesis of 4-chromanones by condensation of 2-hydroxyacetophenones with formaldehyde can be avoided by the isolation of the Mannich base hydrochlorides and cyclization by titration with potassium hydroxide.

Synthesis and Antifungal Activity of New 1-Vinylimidazoles

Carbonyl compounds I were subjected to an imidazole transfer reaction with N,N'-sulfinyldiimidazole or N,N'-carbonyldiimidazole to obtain the diimidazole II and the monoimidazole III.Various 1-vinylimidazoles IV, derived from o-hydroxyacetophenones by imi

N-Vinylimidazoles and -triazoles and pharmaceutical compositions containing them

Described are N-vinylazoles of the general formula: (wherein R is hydrogen, hydroxy, halogen, C1-C5 alkoxy, C2-C5 alkenyloxy, optionally substituted benzyloxy, tetrahydropyranyl-oxy, difluoromethoxy, 2-(2,4-dich