1639055-97-2Relevant academic research and scientific papers
A synthesis of novel sulfur-linked fused thienotriazolopyrimidine derivatives
Song, Yang-Heon
, p. 423 - 427 (2014/08/18)
The synthesis of new sulfur-linked tetracyclic thienotriazolopyrimidine compounds was reported, respectively, from thieno[3,2-e][1,2,4]triazolo[4,3-c] pyrimidine-3(2H)-thione and thieno[2,3-e][1,2,4]triazolo[4,3-c]pyrimidine-3(2H)- thione through cyclization. The reaction mixture was diluted with water, and the solid was filtered, dried and recrystallized from ethanol. Treatment of thieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidine-3(2H)-thione and thieno[2,3-e][1,2,4]triazolo[4,3-c]pyrimidine-3(2H)-thione with methyl iodide in the presence of sodium acetate, and the subsequent reaction of the resultant compounds with hydrazine led to the replacement of thiomethyl group to afford 3-hydrazinothienotriazolopyrimidines. This substitution reaction gave better yield compared to the reaction of chlorothienotriazolopyrimidine with hydrazine.
