1639124-63-2Relevant academic research and scientific papers
Asymmetric synthesis of (-)-pterosin N from a chiral 1,3-dioxolanone
Wu, Hsiu-Han,Hsu, Shao-Chien,Hsu, Feng-Lin,Uang, Biing-Jiun
, p. 4351 - 4355 (2014/07/21)
The first asymmetric total synthesis of (-)-pterosin N from the N,N-diisopropyl-10-camphorsulfonamide-derived chiral 1,3-dioxolanone 11 has been accomplished in 9 steps with 8% overall yield. The key steps in this synthesis were the highly stereoselective propargylation of 1,3-dioxolanone 11 to construct the chiral tertiary alcohol moiety, construction of a diene-ynone by Stille coupling, and an intramolecular Diels-Alder reaction followed by aromatization to finish the synthesis. Copyright
