163936-78-5

Basic information

• Product Name: 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide
• Synonyms: 2H-1,2,4-Benzothiadiazine, 7-chloro-3,4-dihydro-3-methyl-, 1,1-dioxide; 7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide; 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide; 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-S,S-dioxide
• CAS NO: 163936-78-5
• Molecular Formula: C₈H₉ClN₂O₂S
• Molecular Weight: 232.6873
• Mol File: 163936-78-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 405.1°C at 760 mmHg
• Flash Point: 198.8°C
• Density: 1.394g/cm³
• Vapor Pressure: 8.98E-07mmHg at 25°C
• Refractive Index: 1.571
• CAS DataBase Reference: 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide(163936-78-5)
• EPA Substance Registry System: 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide(163936-78-5)

Safety Data

• Hazardous Substances Data: 163936-78-5(Hazardous Substances Data)

Upstream product

• 5790-69-2 2-amino-5-chlorobenzenesulfonamide 
• 64-17-5 ethanol 
• 17800-60-1 2-acetylamino-benzenesulfonic acid acetylamide 
• 90794-87-9 4-Chlor-2-acetylsulfamoyl-acetanilid 
• 75-07-0 acetaldehyde 

Downstream Products

• 19900-92-6 N-acetyl-5-chloro-2-nitrobenzenesulfonamide 

Relevant articles and documents

Metal-free oxidative cyclization of 2-amino-benzamides, 2-aminobenzenesulfonamide or 2-(aminomethyl)anilines with primary alcohols for the synthesis of quinazolinones and their analogues

A general metal-free oxidative cyclization process has been developed for the synthesis of quinazolinones, benzothiadiazines and quinazolines. By this protocol, a range of substituted 2-aminobenzamides, 2-aminobenzenesulfonamide and 2-(aminomethyl)anilines react with various alcohols, leading to the desired annulated products smoothly. This protocol features many advantages as broad substrate scope, mild reaction conditions, low environmental pollution, high atom-economy and good to excellent yields.

ANTIHYPERTENSIVE AGENTS. I. NON-DIURETIC 2H-1,2,4-BENZOTHIADIAZINE

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