1639370-67-4

Basic information

• Product Name: methyl 2-(3-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)benzoate
• Synonyms: methyl 2-(3-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)benzoate
• CAS NO: 1639370-67-4
• Molecular Weight: 294.31
• Mol File: 1639370-67-4.mol

Chemical Properties

• CAS DataBase Reference: methyl 2-(3-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(3-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)benzoate(1639370-67-4)
• EPA Substance Registry System: methyl 2-(3-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)benzoate(1639370-67-4)

Safety Data

• Hazardous Substances Data: 1639370-67-4(Hazardous Substances Data)

Upstream product

• 26963-23-5 isoindolo[2,1-a]quinazolin-5-(11H)-one 
• 74-88-4 methyl iodide 

Relevant articles and documents

On the peculiar reactivity of a C,N-annelated isoindole core

C-, N-, and/or O-methylation products were generated from 11H-isoindolo[2,1-a]quinazoline-5-one upon treatment with NaH followed by iodomethane under air, and possible recrystallization from methanol. Two products were fully characterized by NMR and X-ray diffraction analysis. In accordance with the HSAB principle, this soft methylating agent (MeI) leads mainly to the C,C-dimethylated product 11,11-dimethyl-11H-isoindolo[2,1-a] quinazoline-5-one, which was previously not observed, beside the N-methylated product, in a procedure using methyl tosylate as a hard methylating agent of the same substrate in the initial absence of a base. A mechanism is finally proposed for the formation of methyl 2-(3-methyl-4-oxo-3,4-dihydroquinazolin-2- yl)benzoate as an oxidation side product. TUeBITAK.