1639424-00-2

Upstream product

• 1374774-23-8 3-(3-cyanopropoxy)[1]benzofuran-2-carbonitrile 

Downstream Products

• 1639454-49-1 4-amino-2-(4-methylphenyl)-5,6-dihydro[1]benzofuro[3′,2′:2,3]oxepino[4,5-d]pyrimidine 
• 1639454-54-8 4-methylamino-2-(4-methylphenyl)-5,6-dihydro[1]benzofuro[3′,2′:2,3]oxepino[4,5-d]pyrimidine 
• 1639454-59-3 4-dimethylamino-2-(4-methylphenyl)-5,6-dihydro[1]benzofuro[3′,2′:2,3]oxepino[4,5-d]pyrimidine 
• 1639454-64-0 4-ethylamino-2-(4-methylphenyl)-5,6-dihydro[1]benzofuro[3′,2′:2,3]oxepino[4,5-d]pyrimidine 
• 1639454-69-5 4-(2-hydroxyethylamino)-2-(4-methylphenyl)-5,6-dihydro[1]benzofuro[3′,2′:2,3]oxepino[4,5-d]pyrimidine 
• 1639424-10-4 4-ethoxy-2-(4-methylphenyl)-5,6-dihydro[1]benzofuro[3',2':2,3]oxepino[4,5-d]pyrimidine 
• 1639424-12-6 4-ethoxy-5-methyl-2-(4-methylphenyl)[1]benzofuro[2',3':5,6]pyrano[4,3-d]pyrimidine 
• 1639424-05-7 4-methoxy-2-(4-methylphenyl)-5,6-dihydro[1]benzofuro[3',2':2,3]oxepino[4,5-d]pyrimidine 
• 1639424-24-0 4-(2-hydroxyethylsulfanyl)-2-(4-methylphenyl)-5,6-dihydro[1]benzofuro[3',2':2,3]oxepino[4,5-d]pyrimidine 
• 1639424-19-3 4-(2-hydroxyethoxy)-2-(4-methylphenyl)-5,6-dihydro[1]benzofuro[3',2':2,3]oxepino[4,5-d]pyrimidine 

Relevant academic research and scientific papers

Polycyclic N-heterocyclic compounds 76: Synthesis and antiplatelet evaluation of 2,4-disubstituted 5,6-Dihydro[1]benzofuro[3′,2′:2,3] oxepino[4,5-d]pyrimidines

Reaction of several Vilsmeier reagents with 5-amino-2,3-dihydro[1] benzofuro[3,2-b]oxepin-4-carbonitrile gave tetracyclic 2-substituted 4-chloro-5,6-dihydro[1]benzofuro[3′,2′:2,3]oxepino[4,5-d] pyrimidines. The structure of one of these, the 4-chloro-2-phenyl derivative, was confirmed by X-ray crystallography. Treatment of the 4-chloro derivatives with simple amines as nucleophile afforded 2-substituted 4-amino derivatives. A pentacyclic compound was also obtained by dehydrative ring closure. These products were evaluated for antiplatelet activity, and some showed potency comparable with that of aspirin.