1639428-83-3Relevant academic research and scientific papers
Total synthesis of phenanthroindolizidine alkaloids via asymmetric deprotonation of N-Boc-pyrrolidine
Deng, Meng,Su, Bo,Zhang, Hui,Liu, Yuxiu,Wang, Qingmin
, p. 14979 - 14984 (2014/04/17)
A concise and efficient enantioselective strategy to synthesize two typical phenanthroindolizidine alkaloids, 14-hydroxyantofine and antofine, was developed, featuring an asymmetric deprotonation/diastereoselective carbonyl addition sequence during which the formation of a chiral C-13a center and connection of pyrrolidine and phenanthrene moieties were achieved efficiently in one step. The absolute configuration of the C-13a stereocenter can be delicately controlled by using different enantiomers of sparteine, both of which are commercially available. This journal is the Partner Organisations 2014.
