1639789-08-4

Basic information

• Product Name: 4-chloro-2-(1-(2,4-dimethylphenyl)-1H-pyrazol-4-yl)-3,3,7-trimethyl-3H-indole
• CAS NO: 1639789-08-4
• Molecular Weight: 363.89
• Mol File: 1639789-08-4.mol

Chemical Properties

• CAS DataBase Reference: 4-chloro-2-(1-(2,4-dimethylphenyl)-1H-pyrazol-4-yl)-3,3,7-trimethyl-3H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-2-(1-(2,4-dimethylphenyl)-1H-pyrazol-4-yl)-3,3,7-trimethyl-3H-indole(1639789-08-4)
• EPA Substance Registry System: 4-chloro-2-(1-(2,4-dimethylphenyl)-1H-pyrazol-4-yl)-3,3,7-trimethyl-3H-indole(1639789-08-4)

Safety Data

• Hazardous Substances Data: 1639789-08-4(Hazardous Substances Data)

Upstream product

• 1639789-03-9 2-(4-chloro-1,3-dihydro-3,3,7-trimethyl 2H-indol-2-ylidene)propanedial 
• 60480-83-3 (2,4-dimethylphenyl)hydrazine hydrochloride 
• 1639789-02-8 4-chloro-2,3,3,7-tetramethyl-3H-indole 
• 563-80-4 3-methyl-butan-2-one 
• 5446-17-3 5-chloro-2-methylphenylhydrazine hydrochloride 

Relevant articles and documents

The synthesis of new heterocycles using 2-(4-Chloro-1,3-dihydro-3,3,7- trimethyl-2H-indol-2-ylidene) propanedial

4-Chloro-2,3,3,7-tetramethyl-3H-indole (an indolenine) was produced by the reaction of 5-chloro-2-methylphenylhydrazine hydrochloride with 3-methylbutan-2-one via Fischer reaction. Exposure of the indolenine to the Vilsmeier reagent at 50C produced a β-diformyl compound, 2-(4-chloro-1,3-dihydro-3,3,7-trimethyl-2H-indol-2-ylidene)propanedial. This dialdehyde was reacted with arylhydrazines, acetamidinium chloride, urea, thiourea, guanidinium chloride, and cyanoacetamide to give various 5-membered and 6-membered heterocyclic products, each carrying a 4-chloro-3,3,7-trimethyl- 3H-indol-2-yl unit as a substituent, in excellent yields.