1639883-27-4Relevant academic research and scientific papers
The use of cobalt-mediated cycloisomerisation of ynedinitriles in the synthesis of pyridazinohelicenes
Chercheja, Serghei,Klivar, Jiri,Jancarik, Andrej,Rybacek, Jiri,Salzl, Simon,Tarabek, Jan,Pospisil, Lubomir,Vacek Chocholousova, Jana,Vacek, Jaroslav,Pohl, Radek,Cisarova, Ivana,Stary, Ivo,Stara, Irena G.
supporting information, p. 8477 - 8482 (2014/07/08)
A cobalt-mediated [2+2+2] cycloisomerisation of ynedinitriles to helical pyridazines in good to high yields was developed. The construction of the pyridazine nucleus from one alkyne and two nitrile units is proposed to follow either a conventional organometallic mechanism or to be triggered by a single-electron transfer from a CoII species. Various [5]-, [6]- and [7]helicene pyridazines were prepared.
