16400-98-9

Basic information

• Product Name: 2-chlorobenzimidazo[1,2-c]quinazolin-6(12H)-one
• CAS NO: 16400-98-9
• Molecular Formula: C₁₄H₈ClN₃O
• Molecular Weight: 269.6858
• Mol File: 16400-98-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 372.9°C at 760 mmHg
• Flash Point: 179.3°C
• Density: 1.57g/cm³
• Vapor Pressure: 9.33E-06mmHg at 25°C
• Refractive Index: 1.79
• CAS DataBase Reference: 2-chlorobenzimidazo[1,2-c]quinazolin-6(12H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chlorobenzimidazo[1,2-c]quinazolin-6(12H)-one(16400-98-9)
• EPA Substance Registry System: 2-chlorobenzimidazo[1,2-c]quinazolin-6(12H)-one(16400-98-9)

Safety Data

• Hazardous Substances Data: 16400-98-9(Hazardous Substances Data)

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 622-58-2 p-Tolylisocyanate 
• 10173-75-8 2-(5-Chlor-2-nitro-phenyl)-benzimidazol 

Relevant articles and documents

Synthesis of imidazo[1,2-c]quinazolin-5(6H)-ones and benzimidazo[1,2-c] quinazolin-6(5H)-ones with the aid of low-valent titanium reagent

(Chemical Equation Presented) A short and facile synthesis of imidazo[1,2-c]quinazolin-5(6H)-ones and benzimidazo[1,2-c]quinazolin-6(5H)-ones was accomplished in good yields via the novel reductive cyclization of 2-(2-nitrophenyl)-imidazoles or 2-(2-nitrophenyl)benzoimidazoles with isocyanates promoted by low-valent titanium reagent.

Synthetic method of benzimidazole-quinazolinone compound

The invention discloses a synthetic method of a benzimidazole-quinazolinone compound, and belongs to the field of organic synthesis. The synthetic method uses an alpha-ketoamide compound which is represented by a formula I shown in the description and an o-phenylenediamine compound which is represented by a formula II shown in the description as substrates, and under the action of catalysts and alkalis, the benzimidazole-quinazolinone compound which is represented by a formula III shown in the description is obtained by reaction. The synthetic method of the invention is based on a novel and efficient mechanism of action to prepare the benzimidazole-quinazolinone compound, and has the advantages of cheap raw materials, chip and easily available catalysts, high efficiency, environmental protection, wide substrate range, high yield, simple operation and the like.