16400-98-9Relevant academic research and scientific papers
Synthesis of imidazo[1,2-c]quinazolin-5(6H)-ones and benzimidazo[1,2-c] quinazolin-6(5H)-ones with the aid of low-valent titanium reagent
Zhao, Xuan,Shi, Da-Qing
, p. 524 - 527 (2010)
(Chemical Equation Presented) A short and facile synthesis of imidazo[1,2-c]quinazolin-5(6H)-ones and benzimidazo[1,2-c]quinazolin-6(5H)-ones was accomplished in good yields via the novel reductive cyclization of 2-(2-nitrophenyl)-imidazoles or 2-(2-nitrophenyl)benzoimidazoles with isocyanates promoted by low-valent titanium reagent.
Copper-Catalyzed C–C Bond Cleavage/Double Cyclization of α-Ketoamides with o-Phenylene Diamines: Synthesis of Benzimidazo[1,2-c]quinazolin-6-ones
Zou, Liang-Hua,Yan, Cheng,Shi, Kai,Su, Liang,Zhu, Shuai,Jia, Zhe-Kang,Wang, Qiuan
supporting information, p. 7725 - 7729 (2019/12/24)
A highly regioselective C–C bond cleavage/double cyclization of α-ketoamides with o-phenylene diamines has been developed for the synthesis of benzimidazo[1,2-c]quinazolin-6-ones. Two new C–N and one new C=N bonds are simultaneously formed in the reaction, providing the gateway to access these fused heterocyclic scaffolds via copper catalysis under air atmosphere. This new protocol provides a novel and important foundation for the preparation of these heterocycles.
Synthetic method of benzimidazole-quinazolinone compound
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Paragraph 0070-0074, (2019/10/04)
The invention discloses a synthetic method of a benzimidazole-quinazolinone compound, and belongs to the field of organic synthesis. The synthetic method uses an alpha-ketoamide compound which is represented by a formula I shown in the description and an o-phenylenediamine compound which is represented by a formula II shown in the description as substrates, and under the action of catalysts and alkalis, the benzimidazole-quinazolinone compound which is represented by a formula III shown in the description is obtained by reaction. The synthetic method of the invention is based on a novel and efficient mechanism of action to prepare the benzimidazole-quinazolinone compound, and has the advantages of cheap raw materials, chip and easily available catalysts, high efficiency, environmental protection, wide substrate range, high yield, simple operation and the like.
