1640282-31-0 Usage
Uses
I-CBP112 has been used in cell culture and sample preparation, to verify the acetylation of VPS34 (vacuolar protein sorting 34), by p300 at K29, K771 and K781 and to diminish synergistic gene expression.
Biochem/physiol Actions
I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors CREBBP (CBP) and EP300 (IC50 = 0.142 and 0.625 μM, respectively). I-CBP112 has little activity against other bromodomains at concentrations up to 1 mM. For full characterization details, please see I-CBP112 on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
Check Digit Verification of cas no
The CAS Registry Mumber 1640282-31-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,4,0,2,8 and 2 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1640282-31:
(9*1)+(8*6)+(7*4)+(6*0)+(5*2)+(4*8)+(3*2)+(2*3)+(1*1)=140
140 % 10 = 0
So 1640282-31-0 is a valid CAS Registry Number.