I-CBP112 is a compound utilized in various scientific applications, particularly in the field of cell biology and molecular research. It is known for its role in verifying the acetylation of VPS34 (vacuolar protein sorting 34) by p300 at specific lysine residues, which is crucial for understanding the regulation of cellular processes.
1640282-31-0
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Basic information
- Product Name: I-CBP112
- Synonyms: I-CBP112;1-[7-(3,4-Dimethoxyphenyl)-9-[[(3S)-1-methylpiperidin-3-yl]methoxy]-2,3,4,5-tetrahydro-1,4-benzoxazepin-4-yl]propan-1-one;I-CBP112, 1640282-31-0;I-CBP112 hydrochloride
- CAS NO:1640282-31-0
- Molecular Formula: C27H36N2O5
- Molecular Weight: 468.59
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1640282-31-0.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 623.5±55.0 °C(Predicted)
- Flash Point: N/A
- Appearance: /
- Density: 1.129±0.06 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: 2-8°C
- Solubility: N/A
- PKA: 9.07±0.10(Predicted)
- CAS DataBase Reference: I-CBP112(CAS DataBase Reference)
- NIST Chemistry Reference: I-CBP112(1640282-31-0)
- EPA Substance Registry System: I-CBP112(1640282-31-0)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- RIDADR: UN 3077 9 / PGIII
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1640282-31-0(Hazardous Substances Data)
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1640282-31-0 Usage
Uses
Used in Cell Biology Research:I-CBP112 is used as a research tool for studying the acetylation of VPS34 by p300 at K29, K771, and K781. This application is essential for understanding the regulation of cellular processes and the role of acetylation in these processes.
Used in Sample Preparation:
I-CBP112 is also used in sample preparation for cell culture experiments. Its role in these experiments is to help researchers verify the acetylation of VPS34, which can provide valuable insights into the underlying mechanisms of cellular regulation and gene expression.
Used in Gene Expression Studies:
I-CBP112 is employed as a tool to diminish synergistic gene expression. By understanding how this compound affects gene expression, researchers can gain a better understanding of the complex interactions between genes and proteins within the cell, ultimately contributing to the development of targeted therapies and treatments for various diseases.
Biochem/physiol Actions
I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors CREBBP (CBP) and EP300 (IC50 = 0.142 and 0.625 μM, respectively). I-CBP112 has little activity against other bromodomains at concentrations up to 1 mM. For full characterization details, please see I-CBP112 on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgcCheck Digit Verification of cas no
The CAS Registry Mumber 1640282-31-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,4,0,2,8 and 2 respectively; the second part has 2 digits, 3 and 1 respectively.Calculate Digit Verification of CAS Registry Number 1640282-31:
(9*1)+(8*6)+(7*4)+(6*0)+(5*2)+(4*8)+(3*2)+(2*3)+(1*1)=140
140 % 10 = 0
So 1640282-31-0 is a valid CAS Registry Number.
1640282-31-0Upstream product
1640282-31-0Downstream Products
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I-CBP112
