164062-69-5 Usage
Uses
Used in Pharmaceutical Synthesis:
2-(4-ethyl-phenyl)-1H-imidazole is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of bioactive compounds with potential therapeutic applications.
Used in Agrochemical Development:
In the agrochemical industry, 2-(4-ethyl-phenyl)-1H-imidazole is utilized as a building block in the creation of new agrochemicals, leveraging its imidazole-based structure to enhance the effectiveness of these products.
Used in Medicinal Chemistry Research:
As a component in medicinal chemistry, 2-(4-ethyl-phenyl)-1H-imidazole is used as a starting material for the synthesis of compounds with potential applications in drug discovery and the treatment of various diseases.
Used in Coordination Chemistry:
2-(4-ethyl-phenyl)-1H-imidazole serves as a ligand in coordination chemistry, playing a crucial role in the formation of coordination compounds that have applications in catalysis, materials science, and other areas.
Used in Organic Synthesis:
Recognizing its importance in organic synthesis, 2-(4-ethyl-phenyl)-1H-imidazole is employed in the development of new molecules with potential therapeutic properties, contributing to the advancement of chemical libraries and the discovery of novel pharmaceutical agents.
Check Digit Verification of cas no
The CAS Registry Mumber 164062-69-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,4,0,6 and 2 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 164062-69:
(8*1)+(7*6)+(6*4)+(5*0)+(4*6)+(3*2)+(2*6)+(1*9)=125
125 % 10 = 5
So 164062-69-5 is a valid CAS Registry Number.
164062-69-5Relevant academic research and scientific papers
Discovery of 4-aryl-2-benzoyl-imidazoles as tubulin polymerization inhibitor with potent antiproliferative properties
Xiao, Min,Ahn, Sunjoo,Wang, Jin,Chen, Jianjun,Miller, Duane. D.,Dalton, James T,Li, Wei
, p. 3318 - 3329 (2013/06/26)
A series of 4-aryl-2-benzoyl-imidazoles were designed and synthesized based on our previously reported 2-aryl-4-benzoyl-imidazole (ABI) derivatives. The new structures reversed the aryl group and the benzoyl group of previous ABI structures and were named as reverse ABI (RABI) analogues. RABIs were evaluated for biological activity against eight cancer cell lines including multidrug-resistant cancer cell lines. In vitro assays indicated that several RABI compounds had excellent antiproliferative properties, with IC50 values in the low nanomolar range. The average IC50 of the most active compound 12a is 14 nM. In addition, the mechanism of action of these new analogues was investigated by cell cycle analysis, tubulin polymerization assay, competitive mass spectrometry binding assay, and molecular docking studies. These studies confirmed that these new RABI analogues maintain their mechanisms of action by disrupting tubulin polymerization, similar to their parental ABI analogues.
