164070-40-0Relevant academic research and scientific papers
The chemical synthesis of bioactive glycosylphosphatidylinositols from Trypanosoma cruzi containing an unsaturated fatty acid in the lipid
Yashunsky, Dmitry V.,Borodkin, Vladimir S.,Ferguson, Michael A. J.,Nikolaev, Andrei V.
, p. 468 - 474 (2007/10/03)
(Chemical Equation Presented) Protection strategy: Glycosylphosphatidylinositols (GPIs) from the Trypanosoma cruzi parasite (a causative agent of Chagas' disease) that contain an unsaturated fatty acid in the lipid moiety (see partial structure of 1, R = (CH2) 7CH=CH-(CH2)7CH3, and 2, R = (CH2)7CH= CHCH2CH=CH(CH2) 4CH3) were prepared by a strategy that employs non-benzyl-type protecting groups. The synthetic GPIs show similar biological activity to their natural counterparts.
