164083-84-5 Usage
Uses
Used in Pharmaceutical and Biomedical Research:
[3-[[3-(2-Amino-2-oxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-5-yl]oxy]propyl]-phosphonicacid is used as an inhibitor of Group IIA sPLA2 for the purpose of studying the role of this enzyme in biological systems and its involvement in inflammatory processes. Its high selectivity allows researchers to differentiate the actions of Group IIA sPLA2 from those of other sPLA2 isoforms, providing valuable insights into the specific mechanisms and pathways influenced by this enzyme.
Used in Anti-inflammatory Applications:
In the field of anti-inflammatory drug development, [3-[[3-(2-Amino-2-oxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-5-yl]oxy]propyl]-phosphonicacid is used to block Pseudomonas aeruginosa cytotoxicity, which is a significant factor in the pathogenesis of various inflammatory conditions. By inhibiting the activity of Group IIA sPLA2, LY 311727 can potentially reduce the inflammatory response and associated tissue damage caused by this bacterium.
Used in Modulation of Eicosanoid Synthesis:
[3-[[3-(2-Amino-2-oxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-5-yl]oxy]propyl]-phosphonicacid is used to attenuate VEGF-mediated platelet-activating factor (PAF) synthesis in HUVEC and BAEC cells. This application is significant in the context of vascular biology, as PAF is a potent mediator of inflammation and plays a crucial role in the regulation of vascular permeability and platelet aggregation. By modulating PAF synthesis, LY 311727 may contribute to the development of therapeutic strategies for conditions involving abnormal vascular function and inflammation.
Biochem/physiol Actions
LY311727 is an orally active; potent secretory Phospholipase A2 (sPLA2; Group IIa) inhibitor.
Check Digit Verification of cas no
The CAS Registry Mumber 164083-84-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,4,0,8 and 3 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 164083-84:
(8*1)+(7*6)+(6*4)+(5*0)+(4*8)+(3*3)+(2*8)+(1*4)=135
135 % 10 = 5
So 164083-84-5 is a valid CAS Registry Number.
InChI:InChI=1/C22H27N2O5P/c1-2-20-19(14-22(23)25)18-13-17(29-11-6-12-30(26,27)28)9-10-21(18)24(20)15-16-7-4-3-5-8-16/h3-5,7-10,13H,2,6,11-12,14-15H2,1H3,(H2,23,25)(H2,26,27,28)
