164165-05-3Relevant academic research and scientific papers
Zinca-en-allene cyclization synthesis of substituted tetrahydrofurans
Lorthiois, Edwige,Marek, Ilane,Meyer, Christophe,Normant, Jean-F.
, p. 1263 - 1266 (1995)
The synthesis of polysubstituted tetrahydrofurans, in a two-step procedure from common intermediants, is readily available by the new zinca-en-allene reaction. This strategy allows the creation of vicinal quaternary and tertiary centers or of two quaterna
Zinca-ene-allene cyclizations: A way to substituted tetrahydrofurans or pyrrolidines
Lorthiois, Edwige,Marek, Ilane,Normant, Jean-Francois
, p. 333 - 342 (2007/10/03)
Polysubstituted enynes have been lithiated on the propargylic position, and transmetalation to the corresponding zinc reagents promotes an easy cyclization reaction leading to polysubstituted tetrahydrofurans and pyrrolidines of definite geometry via the zinca-ene-allene reaction.Keywords: carbocyclization; allenyl zinc; tetrahydrofuran; pyrrolidine; zinca-ene-allene
