16417-38-2

Basic information

• Product Name: N-Palmitoyl-L-serine
• Synonyms: N-HEXADECANOYL-SERINE;N-palmitoyl-L-serine;2-(Hexadecanoylamino)-3-hydroxypropanoic acid;N-(1-Oxohexadecyl)-L-serine;Einecs 240-466-4
• CAS NO: 16417-38-2
• Molecular Formula: C₁₉H₃₇NO₄
• Molecular Weight: 343.5
• EINECS: 240-466-4
• Mol File: 16417-38-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 96-99 °C
• Boiling Point: 540 °C at 760 mmHg
• Flash Point: 280.4 °C
• Appearance: /
• Density: 1.008g/cm³
• Vapor Pressure: 6.5E-14mmHg at 25°C
• Refractive Index: 1.479
• PKA: 3.28±0.10(Predicted)
• CAS DataBase Reference: N-Palmitoyl-L-serine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Palmitoyl-L-serine(16417-38-2)
• EPA Substance Registry System: N-Palmitoyl-L-serine(16417-38-2)

Safety Data

• Hazardous Substances Data: 16417-38-2(Hazardous Substances Data)

Usage

General Description

N-Palmitoyl-L-serine is a chemical compound belonging to the class of lipids known as palmitoyl serine. It is derived from the amino acid L-serine, which is palmitoylated with a 16-carbon saturated fatty acid (palmitic acid). N-Palmitoyl-L-serine is known for its potential skin moisturizing and protective properties, making it a popular ingredient in skincare and cosmetic products. N-Palmitoyl-L-serine is also believed to have anti-inflammatory and anti-aging effects on the skin, making it a sought-after ingredient in anti-aging and wrinkle-reducing skincare formulations. Additionally, it has been studied for its potential use in drug delivery systems and in the treatment of certain skin conditions, demonstrating its versatility and potential applications in both skincare and pharmaceutical industries.

InChI:InChI=1/C19H37NO4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(22)20-17(16-21)19(23)24/h17,21H,2-16H2,1H3,(H,20,22)(H,23,24)/t17-/m0/s1

Upstream product

• 114134-57-5 N-hexadecanoyl-L-serine methyl ester 
• 56776-06-8 N-(palmitoyloxy)succinimide 
• 57-10-3 1-hexadecylcarboxylic acid 
• 56-45-1 L-serin 
• 1492-30-4 4-nitrophenyl palmitate 
• 14464-31-4 palmitic acid N-succinimide ester 
• 112-67-4 n-hexadecanoyl chloride 

Downstream Products

• 947325-42-0 3-(tert-butyldimethylsilanyloxy)-2-(S)-hexadecanoylaminothiopropionic acid S-phenyl ester 
• 947325-41-9 2-(S)-hexadecanoylamino-3-hydroxythiopropionic acid S-phenyl ester 

Relevant articles and documents

The relationship between the structure and properties of amino acid surfactants based on glycine and serine

Two series of surfactants based on glycine and serine were synthesized with aproic acid, octanoic acid, decanoic acid, dodecanoic acid, tetradecanoic acid and hexadecanoic acid. All the surfactants were characterized by MS and 1H NMR, the structures of the synthesized surfactants are correct and the signals in MS and 1H NMR can be explained. The reaction conditions, surface properties and foam properties were studied. For the two series of surfactants, critical micelle concentration (CMC) and γ CMC (surface tension at CMC) decrease and surface activity is enhanced as the length of carbon chain increases. The surfactants with tetradecanoyl and hexadecanoyl groups show a good foaming property and especially, the long-chain acyl-serine performs better. These are all related to the hydromethyl group in the serine.

AMIDES OF MONO AND DICARBOXYLIC ACIDS WITH GLYCOSAMINES, SELECTIVELY ACTIVE ON THE CANNABINOID PERIPHERAL RECEPTOR

-