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1642-54-2

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1642-54-2 Usage

Chemical Properties

White or almost white, crystalline powder, slightly hygroscopic.

Originator

Hetrazan,Lederle,US,1949

Uses

Diethylcarbamazine Citrate can be used as an anthelmintic. The LD50 in rats is 1.38 g/kg.

Manufacturing Process

To 50 cc of water was added 18 grams of 1-methylpiperazine dihydrochloride and 8.34 grams of sodium hydroxide. When solution had been effected the beaker was cooled to 10°C and with stirring, 4.17 grams of sodium hydroxide dissolved in 15 cc of water and 14 grams of diethyl carbamyl chloride were added simultaneously. When all had been added, the solution was extracted 3 times with ether which was then dried and filtered. The ether solution was saturated with dry hydrogen chloride. A yellow gum appeared which on trituration gave a white, hygroscopic solid which was filtered and dried in a drying pistol. The N,N-diethyl-4-methyl-1-piperazine-carboxamide hydrochloride had a melting point of 150°-155°C.If the compound itself is desired, the salt is dissolved in water and the solution saturated with a mild alkali such as potassium carbonate. The product is then extracted with chloroform, dried, and after removal of the chloroform, distilled.

Therapeutic Function

Anthelmintic

General Description

Crystalline solid, scored white tablets. Used against filariasis in man and animals.

Health Hazard

(Non-Specific -- Drugs, n.o.s.) May be fatal if inhaled, swallowed or absorbed through skin. Contact may cause burns to skin and eyes. Fire may produce irritating or poisonous gases. Runoff from fire control or dilution water may cause pollution. The average adult man tolerates a single dose of 1.5 gm without ill effects.

Fire Hazard

When heated to decomposition, DIETHYLCARBAMAZINE CITRATE emits toxic fumes of nitrogen oxides. Avoid decomposing heat.

Safety Profile

Poison by inhalation and intravenous routes. Moderately toxic by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. When heated to decomposition it emits toxic fumes of NOx.

Veterinary Drugs and Treatments

Once the hallmark agent for heartworm disease prophylaxis in dogs, DEC is no longer commercially available in the USA (in oral veterinary dosage forms). DEC is approved for use for the prophylaxis of heartworm disease (D. immitis), and/or the treatment of ascariasis in dogs. The drug is also used in ferrets and zoo animals susceptible to heartworm. DEC is used in dogs at higher dosages as alternative therapy for several other parasites (see Dosage section below). Some products were labeled for use in cats to treat ascarid infections. In cats, DEC may help alleviate the course (preventing lymphoma development) of FeLV infection. In the U.K., DEC is used as an injectable product to control parasitic bronchitis (Dictyocaulus viviparous) in sheep and cattle. In humans, DEC is indicated as a filaricidal for the treatment of Wucheria bancrofti, Brugia malayi, Loa loa, and Onchocerca volvulus.

Check Digit Verification of cas no

The CAS Registry Mumber 1642-54-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,4 and 2 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1642-54:
(6*1)+(5*6)+(4*4)+(3*2)+(2*5)+(1*4)=72
72 % 10 = 2
So 1642-54-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H21N3O.C6H8O7/c1-4-12(5-2)10(14)13-8-6-11(3)7-9-13;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-9H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3

1642-54-2 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (D1898)  Diethylcarbamazine Citrate  >98.0%(T)

  • 1642-54-2

  • 10g

  • 640.00CNY

  • Detail
  • Sigma-Aldrich

  • (D1300000)  Diethylcarbamazine citrate  European Pharmacopoeia (EP) Reference Standard

  • 1642-54-2

  • D1300000

  • 1,880.19CNY

  • Detail
  • USP

  • (1193006)  Diethylcarbamazine citrate  United States Pharmacopeia (USP) Reference Standard

  • 1642-54-2

  • 1193006-200MG

  • 4,662.45CNY

  • Detail
  • Sigma-Aldrich

  • (31704)  Diethylcarbamazinecitratesalt  VETRANAL, analytical standard

  • 1642-54-2

  • 31704-250MG

  • 329.94CNY

  • Detail
  • Aldrich

  • (D8765)  Diethylcarbamazinecitratesalt  

  • 1642-54-2

  • D8765-25G

  • 1,272.96CNY

  • Detail

1642-54-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name N,N-Diethyl-4-methyl-1-piperazinecarboxamide Citrate

1.2 Other means of identification

Product number -
Other names 1-(N,N-DIETHYLCARBAMOYL)-4-METHYLPIPERAZINE CITRATE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1642-54-2 SDS

1642-54-2Upstream product

1642-54-2Downstream Products

1642-54-2Related news

Probing intermolecular interactions in a DIETHYLCARBAMAZINE CITRATE (cas 1642-54-2) salt by fast MAS 1H solid-state NMR spectroscopy and GIPAW calculations08/06/2019

Fast magic-angle spinning (MAS) NMR is used to probe intermolecular interactions in a diethylcarbamazine salt, that is widely used as a treatment against adult worms of Wuchereria bancrofti which cause a common disease in tropical countries named filariasis. Specifically, a dihydrogen citrate sa...detailed

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