1642597-20-3

Upstream product

• 7411-23-6 3,5-dibromotriazole 
• 99768-12-4 4-methoxycarbonylphenylboronic acid 

Downstream Products

• 1266741-05-2 4-[3,5-bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]benzoic acid methyl ester 
• 201530-41-8 deferasirox 
• 1642597-21-4 methyl 4-(3,5-bis(2-methoxyphenyl)-1H-1,2,4-triazol-1-yl)benzoate 

Relevant academic research and scientific papers

Microemulsion technique for the novel synthesis of deferasirox using metal mediated coupling

A novel and efficient synthesis of Deferasirox has been accomplished using transition metal catalyzed sequential cross coupling reactions. First stage of the synthesis employs the use of Chan-Lam coupling between 3,5-dibromo-1H[1,2,4] triazole and (4-(methoxycarbonyl)-phenyl)boronic acid to give methyl 4-(3,5-dibromo-1H-1,2,4-triazol-1-yl)benzoate which is further elaboarated to Deferasirox by Suzuki-Miyaura coupling with 2-hydroxyphenyl-boronic acid pinacol ester in microemlusion.