16428-75-4

Basic information

• Product Name: L-Serine hydrochloride
• Synonyms: L-SERINE HYDROCHLORIDE SOLUTION;L-Serine hydrochloride;(S)-2-Amino-3-hydroxypropanoic acid hydrochloride
• CAS NO: 16428-75-4
• Molecular Formula: C₃H₇NO₃*ClH
• Molecular Weight: 141.55
• Product Categories: Amino Acids, Peptides and Proteins;Amino AcidsAlphabetic;Life Sciences Standards;S;SA - SM
• Mol File: 16428-75-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 381.2 °C at 760 mmHg
• Flash Point: 184.4 °C
• Appearance: /
• Vapor Pressure: 2.23E-07mmHg at 25°C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: L-Serine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: L-Serine hydrochloride(16428-75-4)
• EPA Substance Registry System: L-Serine hydrochloride(16428-75-4)

Safety Data

• RIDADR: UN 1789
• F: 10
• Hazardous Substances Data: 16428-75-4(Hazardous Substances Data)

Usage

General Description

L-Serine hydrochloride is a chemical compound that is a derivative of the amino acid serine. It is a white crystalline powder that is soluble in water. L-Serine hydrochloride is an important precursor to several essential biomolecules in the body, including proteins, nucleotides, and other amino acids. It is commonly used in cell culture media, pharmaceuticals, and biochemical research. L-Serine hydrochloride is also a key component of the central nervous system and is involved in the synthesis of neurotransmitters such as glycine and D-serine, making it important for neuronal function and communication. Overall, L-Serine hydrochloride is a widely utilized chemical that plays a crucial role in various physiological processes and applications.

InChI:InChI=1/C3H7NO3.ClH/c4-2(1-5)3(6)7;/h2,5H,1,4H2,(H,6,7);1H/t2-;/m0./s1

Upstream product

• 13734-38-8 N-(t-butyloxycarbonyl)-O-(t-butyl)-L-Serine 
• 1334715-72-8 versicoloritide C 
• 56-45-1 L-serin 
• 161771-71-7 methyl (3S)-3-(m-chlorobenzoyloxy)-N-trifluoroacetylalaninate 

Downstream Products

• 5680-80-8 methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride 
• 3262-72-4 (S)-N-(tert-butoxycarbonyl)serine 
• 16354-58-8 N-acetyl-L-serine 
• 93527-55-0 (S)-2-(dibenzylamino)-3-hydroxypropanoic acid 
• 73724-45-5 N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine 
• 7625-65-2 L-carbobenzyloxy-β-chloroalanine 
• 126101-06-2 (3S)-3-hydroxymethyl-2,5-dioxohexahydro-1H-pyrrolo[1,2-a]-imidazole 
• 51887-89-9 β-chloro-L-alanine hydrochloride 
• 25840-83-9 O-trityl-serine 

Relevant articles and documents

Solvent-freeN-Boc deprotection byex situgeneration of hydrogen chloride gas

An efficient, scalable and sustainable method for the quantitative deprotection of thetert-butyl carbamate (N-Boc) protecting group is described, using down to near-stoichiometric amounts of hydrogen chloride gas in solvent-free conditions. We demonstrate theex situgeneration of hydrogen chloride gas from sodium chloride and sulfuric acid in a two-chamber reactor, introducing a straightforward method for controlled and stoichiometric release of HCl gas. The solvent-free conditions allow deprotection of a wide variety ofN-Boc derivatives to obtain the hydrochloride salts in quantitative yields. The procedure obviates the need for any work-up or purification steps providing an uncomplicated green alternative to standard methods. Due to the solvent-free, anhydrous conditions, this method shows high tolerance towards acid sensitive functional groups and furnishes expanded functional group orthogonality.

Cyclopeptides and polyketides from coral-associated fungus, Aspergillus versicolor LCJ-5-4

Three new cyclopentapeptides, versicoloritides A-C (1-3), a new orcinol tetramer, tetraorcinol A (4), and two new lactones, versicolactones A and B (5 and 6) together with three known metabolites, diorcinol, glyantrypine, and cordyol C were isolated from the fermentation broth of the coral-associated fungus Aspergillus versicolor LCJ-5-4. Their structures were elucidated by spectroscopic and chemical methods. The new compounds 1-4 were evaluated for their radical-scavenging activity and antimicrobial activity against Staphylococcus aureus, Escherichia coli, Enterobacter aerogenes, Bacillus subtilis, Pseudomonas aeruginosa, and Candida albicans and cytotoxicity against P388 and Hela cell lines. Compound 4 showed weak radical-scavenging activity against the DPPH radical with an IC50 value of 67 μM.

Stereospecific Synthesis of α-Deuteriated α-Amino Acids: Regiospecific Deuteriation of Chiral 3-Isopropyl-2,5-dimethoxy-3,6-dihydropyrazines

Base-catalysed deuteriation of (3R)- or (3S)-3-isopropyl-2,5-dimethoxy-3,6-dihydropyrazines in refluxing CH3O2H-2H2O gives the -isotopomer in excellent yields without disturbing the stereogenic centre at C-3.These compounds provide convenient and efficient access to a range of (R)- and (S)-α-deuteriated α-amino acids, including serine, aspartic acid, allylglycine and phenylalanine, via alkylation of the butyllithium generated C-6 anion.