1643-15-8

Basic information

• Product Name: 3-METHYLPHENOXYACETIC ACID
• Synonyms: 2-(m-Tolyloxy)acetic acid;(3-methylphenoxy)acetic acid(SALTDATA: FREE);(3-Methylphenoxy)acetic acid, 98+% 5GR;2-(3-methylphenoxy)ethanoic acid;Acetic acid, (m-tolyloxy)-;M-METHYLPHENOXYACETIC;m-Toloxyacetic acid;2-(m-Tolyloxy)
• CAS NO: 1643-15-8
• Molecular Formula: C₉H₁₀O₃
• Molecular Weight: 166.17
• EINECS: 216-698-7
• Product Categories: Phenoxyacetic Acids and Alcohols (substituted)
• Mol File: 1643-15-8.mol
• Article Data: 35

Chemical Properties

• Melting Point: 102-103 °C
• Boiling Point: 300°Cat760mmHg
• Flash Point: 121.4°C
• Appearance: /
• Density: 1.179g/cm³
• Vapor Pressure: 0.000512mmHg at 25°C
• Storage Temp.: 2-8°C
• PKA: pK1:3.203 (25°C)
• Water Solubility: Soluble in water. 4810 mg/L at 25°C
• BRN: 2047572
• CAS DataBase Reference: 3-METHYLPHENOXYACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYLPHENOXYACETIC ACID(1643-15-8)
• EPA Substance Registry System: 3-METHYLPHENOXYACETIC ACID(1643-15-8)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 36/37/38-22
• Safety Statements: 37/39-26
• RTECS: AI9316500
• HazardClass: IRRITANT
• Hazardous Substances Data: 1643-15-8(Hazardous Substances Data)

Usage

Chemical Properties

Slightly beige crystalline powder

InChI:InChI=1/C9H10O3/c1-7-3-2-4-8(5-7)12-6-9(10)11/h2-5H,6H2,1H3,(H,10,11)/p-1

Upstream product

• 5396-24-7 n-propyl chloracetate 
• 3019-89-4 sodium 3-methylphenoxide 
• 108-39-4 3-methyl-phenol 
• 79-11-8 chloroacetic acid 
• 96-32-2 bromoacetic acid methyl ester 
• 139554-51-1 C₁₂H₁₂N₂O₂ 
• 105-36-2 ethyl bromoacetate 
• 66047-01-6 ethyl 3-methylphenoxyacetate 
• 3926-62-3 sodium monochloroacetic acid 
• 63051-20-7 m-tolyloxyacetic acid methyl ester 
• 20227-79-6 3-methylphenolate anion 
• 58590-46-8 Sodium; m-tolyloxy-acetate 

Downstream Products

• 54914-85-1 1,2-di(3-methylphenoxy)ethane 
• 63051-20-7 m-tolyloxyacetic acid methyl ester 
• 133192-74-2 m-tolyloxy-acetic acid p-tolyl ester 
• 133192-73-1 m-tolyloxy-acetic acid m-tolyl ester 
• 133192-72-0 m-tolyloxy-acetic acid o-tolyl ester 
• 1222-21-5 3-Methyl-4-<3-carboxy-propionyl>-phenoxyessigsaeure 
• 25441-24-1 N-Dimethylcarbamoylmethyl-2-m-tolyloxy-acetamide 
• 1642-90-6 4-Acetyl-3-methyl-phenoxyessigsaeure 
• 84744-05-8 Tris(2-oxyethyl) ammonium 3-methylphenoxyacetate 
• 84138-76-1 5-[(3-methylphenoxy)methyl]-1,3,4-thiadiazol-2-amine 
• 136776-27-7 1-Phenothiazin-10-yl-2-m-tolyloxy-ethanone 
• 20895-41-4 6-methylbenzofuran-3(2H)-one 
• 1392217-13-8 6-hydroxy-1,5-di(4-tolyl)-6-(3-tolyloxymethyl)-1,3,5-triazinane-2,4-dithione 
• 1392217-19-4 6-hydroxy-6-(3-tolyloxymethyl)-1,5-di(4-chlorophenyl)-1,3,5-triazinane-2,4-dithione 

Relevant articles and documents

Potential anticancer agents--L. Non-classical antimetabolites. II. Some factors in the design of exoalkylating enzyme inhibitors, particulary of lactic dehydrogenase.

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Design and Synthesis of Novel 4-Hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one Derivatives for Use as Herbicides and Evaluation of Their Mode of Action

In order to develop a novel herbicide containing the β-triketone motif, a series of 4-hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one derivatives were designed and synthesized. The bioassay results showed that compound II15 had good pre-emergent herbicidal activity even at a dosage of 187.5 g ha-1. Moreover, compound II15 showed a broader spectrum of weed control when compared with a commercial herbicide 2,4-dichlorophenoxyacetic acid (2,4-D), and displayed good crop safety to Triticum aestivum L. and Zea mays Linn. when applied at 375 g ha-1 under pre-emergence conditions, which indicated its great potential as a herbicide. More importantly, studying the molecular mode of action of compound II15 revealed that the novel triketone structure is a proherbicide of its corresponding phenoxyacetic acid auxin herbicide, which has a herbicidal mechanism similar to that of 2,4-D. The present work indicates that the 4-hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one motif may be a potential lead structure for further development of novel auxin-type herbicides.

Isoflavone amide derivatives, their preparation method and medical use

The invention belongs to the field of medicinal chemistry, and relates to derivatives of isoflavones amides, as well as a preparation method and medical application of derivatives, in particular to the derivatives of the isoflavones amides with the general formula of (I) shown as the specification, the preparation method and the medical application of the derivatives, particularly the application of the derivatives of the isoflavones amides serving as medicaments for preventing or treating hyperlipemia, adiposis or type-II diabetes.