1643-43-2

Upstream product

• 10354-00-4 5H-dibenzo[a,d]cyclohepten-5-ol 
• 1796-78-7 (5H-dibenzocyclohepten-5-yl)malonic acid 
• 141-82-2 malonic acid 

Downstream Products

• 147900-34-3 (4R-cis)-3-[(5H-Dibenzo[a,d]cyclohepten-5-yl)acetyl]-4-methyl-5-phenyl-2-oxazolidinone 
• 65779-18-2 3-{4-[2-(2-5H-Dibenzo[a,d]cyclohepten-5-yl-acetylamino)-ethyl]-phenyl}-propionic acid 
• 1425088-86-3 C₂₄H₁₈N₄O₂S 
• 1425088-85-2 C₂₆H₂₃N₃S 
• 1425088-82-9 2-(5H-dibenzo[a,d][7]annulen-5-ylacetyl)-N-(3-nitrophenyl)hydrazinecarbothioamides 
• 1425088-81-8 2-(5H-dibenzo[a,d][7]annulen-5-ylacetyl)-N-(4-ethylphenyl)hydrazinecarbothioamides 
• 147900-35-4 (4R,5S)-3-[(R)-2-Azido-2-(5H-dibenzo[a,d]cyclohepten-5-yl)-acetyl]-4-methyl-5-phenyl-oxazolidin-2-one 
• 147900-34-3 (4S,5R)-3-(2-5H-Dibenzo[a,d]cyclohepten-5-yl-acetyl)-4-methyl-5-phenyl-oxazolidin-2-one 
• 597569-66-9 C₂₈H₂₈N₂O₅S 
• 597569-63-6 C₂₇H₂₅FN₂O₅S 
• 65779-17-1 3-{4-[2-(2-5H-Dibenzo[a,d]cyclohepten-5-yl-acetylamino)-ethyl]-phenyl}-propionic acid ethyl ester 

Relevant academic research and scientific papers

Clear cut example of preference for a 6-membered ring radical cyclisation over the homologous 5-membered ring radical cyclisation. The reaction of 5-[bromoalkyl]-5H-dibenzo[a,d]cycloheptenes with Bu3SnH

The radical cyclisation reaction of the 5-[2-bromo-ethyl]-5H-dibenzo[a,d]cycloheptene 4 with Bu3SnH and AIBN led to the cyclised hydrocarbon 5 as major product, whereas the bromo-derivative 8 with Bu3SnH and AIBN gave only the straight chain product 9. An explanation based on the conformational rigidity of dibenzo[a,d]cycloheptene system calculated by AMI method is proposed. Copyright

DIPEPTIDYL PEPTIDASE-IV INHIBITORS

The present invention relates generally to pyrrolidine and thiazolidine DPP-IV inhibitor compounds. The present invention also provides synthetic methods for preparation of such compounds, methods of inhibiting DPP-IV using such compounds and pharmaceutical formulations containing them for treatment of DPP-IV mediated diseases, in particular, Type-2 diabetes.

Cyclic amino acids and derivatives thereof

Novel cyclic amino acids which are useful in preparing biologically active peptides as well as a process for the preparation of D and L enantiomers of the cyclic amino acids are described where an N-protected derivative of the racemic cyclic amino acid is treated with (-)cinchonidine and the resulting salt resolved into the desired enantiomers, as well as derivatives thereof and valuable intermediates used in the process.

CYCLIC DERIVATIVES OF 3,3-DIPHENYLALANINE (DIP) (II), NOVEL α-AMINO ACIDS FOR PEPTIDES OF BIOLOGICAL INTEREST

The chiral and achiral syntheses of novel cyclic derivatives of 3,3-diphenylalanine (DIP) are described.

Pharmaceutical composition having relaxing activity which contains a nitrate ester as active substance

The invention relates to pharmaceutical compositions containing novel nitrate esters, of which it was found that they are useful for the treatment of ischemiatic heart diseases, decompensatio cordis, myocardial infarction and hypertension.