1643156-18-6

Basic information

• Product Name: 4-broMo-5-fluoro-2-hydrazinylbenzoic acid hydrochloride
• Synonyms: 4-broMo-5-fluoro-2-hydrazinylbenzoic acid hydrochloride;EOS-61627
• CAS NO: 1643156-18-6
• Molecular Formula: C7H7BrClFN2O2
• Molecular Weight: 285.4980832
• EINECS: -0
• Mol File: 1643156-18-6.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-broMo-5-fluoro-2-hydrazinylbenzoic acid hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-broMo-5-fluoro-2-hydrazinylbenzoic acid hydrochloride(1643156-18-6)
• EPA Substance Registry System: 4-broMo-5-fluoro-2-hydrazinylbenzoic acid hydrochloride(1643156-18-6)

Safety Data

• Hazardous Substances Data: 1643156-18-6(Hazardous Substances Data)

Usage

General Description

4-bromo-5-fluoro-2-hydrazinylbenzoic acid hydrochloride is a chemical compound that consists of a benzene ring with two substituent groups: bromine at the 4 position and fluorine at the 5 position, as well as a hydrazinyl group at the 2 position. It is also in a hydrochloride form, indicating the presence of a chloride ion. 4-bromo-5-fluoro-2-hydrazinylbenzoic acid hydrochloride can be used in a variety of applications, such as in the synthesis of pharmaceuticals or in chemical research. It is important to handle this chemical with care, as it may have potential hazards and should only be used in a controlled laboratory setting.

Upstream product

• 327-51-5 1,4-dibromo-2,5-difluorobenzene 
• 1374208-42-0 3-fluoro-4-bromo-6-aminobenzoic acid 
• 28314-82-1 4-bromo-2,5-difluorobenzoic acid 
• 1415929-02-0 2-amino-4-bromo-5-fluorobenzoic acid monohydrochloride 
• 1020717-99-0 4-bromo-5-fluoro-2-nitrobenzoic acid 
• 153556-42-4 4-bromo-3-fluorobenzoic acid 

Downstream Products

• 1643368-58-4 BMS-986142 
• 1643368-58-4 6-fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(R)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide 
• 1643156-20-0 ethyl 5-bromo-8-carbamoyl-6-fluoro-2,3,4,9-tetrahydro-1H-carbazole-2-carboxylate 

Relevant articles and documents

Adventures in Atropisomerism: Total Synthesis of a Complex Active Pharmaceutical Ingredient with Two Chirality Axes

A strategy to prepare compounds with multiple chirality axes, which has led to a concise total synthesis of compound 1A with complete stereocontrol, is reported.

Burton's tyrosine kinase inhibitor

The invention provides a Burton's tyrosine kinase inhibitor. Particularly, a compound capable of serving as the Btk inhibitor is obtained through a wide and thorough research. It is shown through experimental results that the compound has a good inhibitin

CARBAZOLE DERIVATIVES

Disclosed are compounds of Formula (I): (I) or a salt thereof, wherein Q, R1a, R1b, R2a, R2b, R3, R4, R5a, R5b, R6a, R6c, R7a, R7b, R7c, and R7d are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.