164334-40-1Relevant academic research and scientific papers
Asymmetric conjugate additions of chiral phosphonamide anions to α,β-unsaturated carbonyl compounds. A versatile method for vicinally substituted chirons
Hanessian, Stephen,Gomtsyan, Arthur,Malek, Nadia
, p. 5623 - 5631 (2007/10/03)
Reactions of anions derived from chiral nonracemic allyl, crotyl, and cinnamyl bicyclic C2-symmetrical phosphonamides with α,β-unsaturated cyclic ketones, esters, lactones, and lactams take place at the γ-position of the reagents. The products are diastereomerically pure or enriched β-substituted carbonyl compounds. The method also provides easy access to vicinal substitution of as many as three stereogenic centers including in some cases quaternary carbon atoms, in a one-pot sequence.
Highly Stereocontrolled Sequential Asymmetric Michael Addition Reactions with Cinnamate Esters - Generation of Three and Four Contiguous Stereogenic Centers on Seven-Carbon Acyclic Motifs
Hanessian, Stephen,Gomtsiyan, Arthur
, p. 7509 - 7512 (2007/10/02)
The reaction of allyl and crotyl bicyclic chiral phosphonamide anions with two cinnamate esters leads to a sequential Michael reaction with excellent diastereoselectivity.The option to quench enolates with methyl iodide greatly enhances the versatility of
