164334-69-4

Basic information

• Product Name: 3-Bromo-4'-chlorobiphenyl
• Synonyms: 3-Bromo-4'-chloro-1,1'-biphenyl;1,1'-Biphenyl, 3-bromo-4'-chloro-
• CAS NO: 164334-69-4
• Molecular Formula: C₁₂H₈BrCl
• Molecular Weight: 267.54892
• EINECS: -0
• Mol File: 164334-69-4.mol

Chemical Properties

• Boiling Point: 328.4±17.0 °C(Predicted)
• Appearance: /
• Density: 1.463±0.06 g/cm3(Predicted)
• Refractive Index: 1.66
• CAS DataBase Reference: 3-Bromo-4'-chlorobiphenyl(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-4'-chlorobiphenyl(164334-69-4)
• EPA Substance Registry System: 3-Bromo-4'-chlorobiphenyl(164334-69-4)

Safety Data

• Hazardous Substances Data: 164334-69-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Bromo-4'-chlorobiphenyl is used as a pharmaceutical intermediate for the synthesis of various drugs and medications. Its unique chemical structure allows it to serve as a building block or a key component in the development of new pharmaceutical compounds, contributing to the advancement of medical treatments and therapies.
As a pharmaceutical intermediate, 3-Bromo-4'-chlorobiphenyl plays a crucial role in the development of drugs targeting a wide range of health conditions and diseases. Its chemical properties enable it to be modified and functionalized to create new molecules with specific therapeutic effects, making it a valuable asset in the pharmaceutical industry.

Upstream product

• 108-86-1 bromobenzene 
• 10312-71-7 1,6-bis-(4-chlorophenyl)-3,4-diacetyl-1,5-hexazadiene 
• 673-41-6 p-chlorobenzenediazonium tetrafluoroborate 

Downstream Products

• 146898-91-1 C₂₄H₁₆Cl₂ 
• 1443049-85-1 2-(4’-chloro-[1,1‘-biphenyl]-3-yl)-4,6-diphenyl-1,3,5-triazine 

Relevant articles and documents

Visible-Light-Promoted, Catalyst-Free Gomberg-Bachmann Reaction: Synthesis of Biaryls

Biaryls were synthesized via a novel visible-light-promoted Gomberg-Bachmann reaction that does not require a photosensitizer or any metal reagents. The formation of an electron donor-acceptor complex between aryl diazonium salts and pyridine allows, under visible-light irradiation, the synthesis of biaryls in moderate-to-high yields.

Aryl radicals from hexazadienes and tetrazenes

Aryl radicals are produced from both ends of the hexazadienes 1 and 2 and from the tetrazene 3, either thermally or photolytically.They attack aromatic compounds in the nucleus, the yield of biaryl being in the range 40-70percent, though it can be made nearly quantitative by using m-dinitrobenzene as additive.The aryl radicals also oxidize 2-propanol to acetone, the reaction products being the halogenobenzene and 1,2-diacetylhydrazine.Photolysis of 1 goes mainly by way of the tetrazene 3, and this may also be a significant pathway in the thermal reaction.Azodiacetylis an intermediate in the thermal reaction of 1 with 2-propanol and may be generally so in all its reactions.Radical induced decomposition is believed to be important in the reactions of 1, 2, and 3, and it is probably responsible for the formation of 1-acetyl-1-arylhydrazines, routinely produced in yields up to 25percent.