1643354-27-1Relevant articles and documents
Preparation method of 4-(4-aminophenyl)morpholin-3-one derivative
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, (2020/09/30)
The invention belongs to the technical field of medicines, and particularly relates to a preparation method of a 4-(4-aminophenyl)morpholin-3-one derivative. The preparation method comprises the following steps: reacting 4-(4-aminophenyl)morpholin-3-one serving as a raw material with a first reactant to obtain a first intermediate product; and in a first solvent and with the first intermediate product as a raw material, adding (S)-N-(2,3-epoxypropyl)phthalimide in batches in multiple times, and carrying out a reaction at a first temperature to obtain a target product, namely the 4-(4-aminophenyl)morpholin-3-one derivative. According to the method, the solvent is optimized, so a conversion rate is improved; the mode of feeding in batches in multiple times and a post-treatment mode (concentration, crystallization, filtration, drying and the like) are used, so the target product with high yield is obtained; and the target product is the 4-(4-aminophenyl)morpholin-3-one derivative, and the method has important significance in effectively controlling the quality of rivaroxaban.
Rivaroxaban impurities and preparing method and application thereof
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Paragraph 0056; 0057, (2017/08/28)
The invention discloses rivaroxaban impurities. The rivaroxaban impurities include the rivaroxaban impurity 6, the rivaroxaban impurity 10, the rivaroxaban impurity 11 and the rivaroxaban impurity 12; in addition, the invention discloses a preparing method and application of the rivaroxaban impurities. By means of the rivaroxaban impurities and the preparing method thereof, the basis is consolidated for rivaroxaban midbodies and raw material medicine and quality researching of compositions of the rivaroxaban impurities. The structural formula is shown in the specification.