1643377-84-7Relevant academic research and scientific papers
Syntheses of fluorooxindole and 2-fluoro-2-arylacetic acid derivatives from diethyl 2-fluoromalonate ester
Harsanyi, Antal,Sandford, Graham,Yufit, Dmitri S.,Howard, Judith A.K.
supporting information, p. 1213 - 1219 (2014/06/10)
Diethyl 2-fluoromalonate ester is utilised as a building block for the synthesis of 2-fluoro-2-arylacetic acid and fluorooxindole derivatives by a strategy involving nucleophilic aromatic substitution reactions with ortho-fluoronitrobenzene substrates followed by decarboxylation, esterification and reductive cyclisation processes.
