1643389-79-0Relevant academic research and scientific papers
Facile construction of densely functionalized thiopyrano[2,3-b]quinolines via three-component reactions catalyzed by l-proline
Kanani, Mehul B.,Patel, Manish P.
, p. 28798 - 28801 (2014)
l-Proline catalyzed, three-component reactions of 2-mercaptoquinoline-3- carbaldehyde, malononitrile and thiol-based nucleophiles were developed for the first time, for the synthesis of various 4H-substituted thiopyrano[2,3-b] quinolines derivatives via a Knoevenagel condensation followed by inter-intramolecular double Michael addition reaction. This transformation leads to the generation of a 4-substituted thiopyran ring, together with one C-C and two C-S bonds in a single operation.
