164358-33-2

Basic information

• Product Name: diethyl (1S,2S)-1,2-dihydroxy-2-phenylethylphosphonate
• Synonyms: diethyl (1S,2S)-1,2-dihydroxy-2-phenylethylphosphonate
• CAS NO: 164358-33-2
• Molecular Weight: 274.254
• Mol File: 164358-33-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: diethyl (1S,2S)-1,2-dihydroxy-2-phenylethylphosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl (1S,2S)-1,2-dihydroxy-2-phenylethylphosphonate(164358-33-2)
• EPA Substance Registry System: diethyl (1S,2S)-1,2-dihydroxy-2-phenylethylphosphonate(164358-33-2)

Safety Data

• Hazardous Substances Data: 164358-33-2(Hazardous Substances Data)

Upstream product

• 20408-33-7 diethyl (E)-(2-phenylethenyl)phosphonate 
• 1574232-42-0 diethyl (1-benzyloxy-2-oxo-2-phenylethyl)phosphonate 
• 1574232-99-7 diethyl (1S,2S)-(1-benzyloxy-2-hydroxy-2-phenylethyl)phosphonate 
• 89268-01-9 (phenylmethoxy)methylphosphonic acid diethyl ester 

Relevant articles and documents

Dynamic kinetic resolution based asymmetric transfer hydrogenation of α-alkoxy-β-ketophosphonates. Diastereo- and enantioselective synthesis of monoprotected 1,2-dihydroxyphosphonates

Dynamic kinetic resolution driven, asymmetric transfer hydrogenation reactions of a wide range of 2-substituted α-alkoxy-β- ketophosphonates 3 were observed to proceed efficiently to give the corresponding 2-substituted α-alkoxy-β-hydroxy phosphonates 4 w

Enantioselective synthesis of threo-α,β-dihydroxyphosphonates by asymmetric dihydroxylation of 1(E)-alkenylphosphonates with AD-mix reagents

Asymmetric dihydroxylation (AD) of 1(E)-alkenylphosphonates with an AD- mix-α or -β reagent was examined to give a series of optically active threo-α,β-dihydroxyphosphonates. Good enantioselectivity (>88% ee) was observed in the AD reaction of 1(E)-alkenylphosphonates with conjugated aromatic substituents. The steric effects of the ester functionality in the course of the dihydroxylation were also evaluated. Enantioselectivity and yield were significantly improved when the AD reaction was carded out with dimethyl phosphonate instead of diethyl phosphonate.

Stereoselective synthesis of dihydroxyphosphonates via asymmetric dihydroxylation of unsaturated phosphonate esters: Synthesis of hydroxyaminophosphonates via cyclic sulfites

Unsaturated phosphonate esters (1) have been subjected to osmium tetroxide catalyzed asymmetric dihydroxylation (AD) using dihydroquinidine and dihydroquinine derivatives as chiral ligands to furnish the optically active diols (2) which have been converte