164366-29-4Relevant academic research and scientific papers
Efficient, "tin-free" radical cyclization to aromatic systems. Synthesis of 5,6,8,9,10,11-hexahydroindolo[2,1-a]isoquinolines
Menes-Arzate, Martha,Martínez, Roberto,Cruz-Almanza, Raymundo,Muchowski, Joseph M.,Osornio, Yazmin M.,Miranda, Luis D.
, p. 4001 - 4004 (2007/10/03)
Efficient radical cyclization of alkyl iodides to various aromatic systems including pyrrole, indole, isoquinolone, pyridone, and benzene, mediated by dicumyl peroxide, is described. The methodology was used to provide access to 5,6,8,9,10,11-hexahydroindolo[2,1-a]isoquinoline derivatives.
A systematic study of reaction of heterocyclic enamines with electrophilic alkynes: A simple and efficient synthetic route to 2- pyridinone-fused heterocycles
Wang, Mei-Xiang,Miao, Wei-Shi,Cheng, Ying,Huang, Zhi-Tang
, p. 14611 - 14622 (2007/10/03)
The reaction of heterocyclic enamines with ethyl propiolate and diethyl acetylenedicarboxylate has been systematically studied. In contrast to their heterocyclic ketene aminal analogues, heterocyclic enamines reacted with electrophilic alkynes via the Michael addition pathway rather than the aza- ene reaction mechanism. In the presence of a strong base such as sodium ethoxide and sodium hydride, the resulting Michael addition products underwent cyclocondensation reaction readily to produce 2-pyridinone-fused heterocycles in good to excellent yield.
