Welcome to LookChem.com Sign In|Join Free
  • or
5-(2-fluoro-phenyl)-3-methyl-isoxazole-4-carboxylic acid ethyl ester is a complex organic compound with the molecular formula C12H10FNO3. It is a derivative of isoxazole-4-carboxylic acid, featuring a 2-fluoro-phenyl group at the 5-position, a methyl group at the 3-position, and an ethyl ester group at the 4-carboxylic acid position. This chemical is known for its potential applications in the pharmaceutical industry, particularly as a building block for the synthesis of various drugs and bioactive molecules. Its structure provides a unique combination of electronic and steric properties, which can influence its reactivity and interaction with biological targets. The compound's synthesis and use often involve advanced organic chemistry techniques, and it may be subject to patent protection depending on its specific application.

1644-02-6

Post Buying Request

1644-02-6 Suppliers

Recommended suppliers

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

1644-02-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1644-02-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,4 and 4 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1644-02:
(6*1)+(5*6)+(4*4)+(3*4)+(2*0)+(1*2)=66
66 % 10 = 6
So 1644-02-6 is a valid CAS Registry Number.

1644-02-6Relevant academic research and scientific papers

Design, synthesis and cytotoxic activities of scopoletin-isoxazole and scopoletin-pyrazole hybrids

Shi, Wei,Hu, Jinglin,Bao, Na,Li, Dongang,Chen, Li,Sun, Jianbo

, p. 147 - 151 (2017)

12 novel scopoletin-isoxazole and scopoletin-pyrazole hybrids were designed, synthesized and their chemical structures were confirmed by HR-MS, IR,1H NMR and13C NMR spectra. The anticancer activities of the newly synthesized compounds were evaluated in vitro against three human cancer cell lines including HCT-116, Hun7 and SW620 by MTT assay. The screening results showed that six compounds (9a, 9c, 9d, 12a, 18b and 18d) exhibited potent cytotoxic activities with IC50values below 20?μM. Besides, we have further evaluated the growth inhibitory activities of six compounds against the human normal tissue cell lines HFL-1. Especially, compound 9d displayed significant anti-proliferative activity with IC50values ranging from 8.76?μM to 9.83?μM and weak cytotoxicity with IC50value of 90.9?μM on normal cells HFL-1, which suggested that isoxazole-based hybrids of scopoletin were an effective chemical modification to improve the anticancer activity of scopoletin.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1 Customer Service

What can I do for you?
Get Best Price

Get Best Price for 1644-02-6