1644-14-0

Basic information

• Product Name: 6-Fluoroquinoxaline
• Synonyms: Quinoxaline, 6-fluoro-
• CAS NO: 1644-14-0
• Molecular Formula: C₈H₅FN₂
• Molecular Weight: 148.14
• Mol File: 1644-14-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 33-35 °C
• Boiling Point: 241.9°C at 760 mmHg
• Flash Point: 100.1°C
• Appearance: /
• Density: 1.297g/cm³
• Vapor Pressure: 0.0543mmHg at 25°C
• Refractive Index: 1.622
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 0.11±0.30(Predicted)
• CAS DataBase Reference: 6-Fluoroquinoxaline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Fluoroquinoxaline(1644-14-0)
• EPA Substance Registry System: 6-Fluoroquinoxaline(1644-14-0)

Safety Data

• Hazardous Substances Data: 1644-14-0(Hazardous Substances Data)

Usage

General Description

6-Fluoroquinoxaline is a chemical compound with the molecular formula C8H5FN2. It is a heterocyclic aromatic compound that contains a fluorine atom, and it is commonly used in the pharmaceutical industry as a building block for the synthesis of various biologically active molecules. 6-Fluoroquinoxaline has been studied for its potential pharmacological properties, including as an antimicrobial and antiviral agent. Its unique structure and fluorine substitution make it a valuable tool for drug discovery and development, and it is of interest to researchers exploring new therapeutic agents for a range of medical conditions.

InChI:InChI=1/C8H5FN2/c9-6-1-2-7-8(5-6)11-4-3-10-7/h1-5H

Upstream product

• 50998-17-9 6-bromoquinoxaline 
• 852432-98-5 (quinoxalin-6-yl)boronic acid 
• 364-78-3 2-nitro-4-fluoroaniline 
• 131543-46-9 Glyoxal 
• 367-31-7 4-fluoro-1,2-phenylenediamine 

Relevant articles and documents

Derisking the Cu-Mediated 18F-Fluorination of Heterocyclic Positron Emission Tomography Radioligands

Molecules labeled with fluorine-18 (18F) are used in positron emission tomography to visualize, characterize and measure biological processes in the body. Despite recent advances in the incorporation of 18F onto arenes, the development of general and efficient approaches to label radioligands necessary for drug discovery programs remains a significant task. This full account describes a derisking approach toward the radiosynthesis of heterocyclic positron emission tomography (PET) radioligands using the copper-mediated 18F-fluorination of aryl boron reagents with 18F-fluoride as a model reaction. This approach is based on a study examining how the presence of heterocycles commonly used in drug development affects the efficiency of 18F-fluorination for a representative aryl boron reagent, and on the labeling of more than 50 (hetero)aryl boronic esters. This set of data allows for the application of this derisking strategy to the successful radiosynthesis of seven structurally complex pharmaceutically relevant heterocycle-containing molecules.

Pd-catalyzed nucleophilic fluorination of aryl bromides

On the basis of mechanism-driven reaction design, a Pd-catalyzed nucleophilic fluorination of aryl bromides and iodides has been developed. The method exhibits a broad substrate scope, especially with respect to nitrogen-containing heteroaryl bromides, and proceeds with minimal formation of the corresponding reduction products. A facilitated ligand modification process was shown to be critical to the success of the reaction.

Fluorination of boronic acids mediated by silver(I) Triflate

A regiospecific Ag-mediated fluorination reaction of aryl- and alkenylboronic acids and esters Is reported. The fluorination reaction uses commercially available reagents, does not require the addition of exogenous ligands, and can be performed on a multigram scale. This report discloses the first practical reaction sequence from arylboronic acid to aryl fluorides.