164401-87-0Relevant academic research and scientific papers
Kinetics and Mechanism of the Reversible Isomerization of Aspartic Acid Residues in Tetrapeptides
Capasso, Sante,Kirby, Anthony J.,Salvadori, Severo,Sica, Filomena,Zagari, Adriana
, p. 437 - 442 (2007/10/02)
The influence of pH and buffer concentration on the rate of the isomerization of Asp residues has been analysed using model aspartic acid-containing tetrapeptides, in the pH range 1.5-10 at 37 deg C and μ=1 mol dm-3.The reaction involves the re
Spontaneous Cyclization of the Aspartic Acid Side Chain to the Succinimide Derivative
Capasso, S.,Mazzarella, L.,Sica, F.,Zagari, A.,Salvadori, S.
, p. 919 - 921 (2007/10/02)
At equilibrium in acidic solution the succinimide derivative, formed by cyclization reaction of the Asp side chain, predominates; at a pH close to the apparent pKa of the Asp residue this reaction is relatively fast with a t1/2 of a few days.
