1644185-69-2Relevant academic research and scientific papers
A novel domino synthesis of quinazolinediones by palladium-catalyzed double carbonylation
Li, Haoquan,Li, Wanfang,Spannenberg, Anke,Baumann, Wolfgang,Neumann, Helfried,Beller, Matthias,Wu, Xiao-Feng
supporting information, p. 8541 - 8544 (2014/07/21)
Combining commercially available bromoanilines and bromobenzonitriles in a novel double carbonylation process allows for a straightforward synthesis of isoindolo[1,2-b]quinazoline-10,12-diones. At least five different C-C and/or C-N bonds are selectively formed in this 3-component reaction, which likely proceeds through sequential carbonylation-cyclization-isomerisation- carbonylation steps. Notably, two molecules of CO are inserted in this highly efficient palladium-catalyzed process.
