1644189-06-9Relevant academic research and scientific papers
Palladium-catalyzed insertion of an allene into an aminal: Aminomethylamination of allenes by C-N bond activation
Hu, Jianhua,Xie, Yinjun,Huang, Hanmin
, p. 7272 - 7276 (2014/07/21)
A new and atom-economic palladium-catalyzed aminomethylamination of allenes with aminals by C-N bond activation is described. This direct and operationally simple method provides a fundamentally novel approach for the synthesis of 1,3-diamines. Mechanistic studies suggest that a unique cationic π-allylpalladium complex containing an aminomethyl moiety is generated as a key intermediate through the carbopalladation of the allene with a cyclometalated palladium-alkyl species.
