1644191-41-2Relevant academic research and scientific papers
Preparation and regioselective metalation of Bis(trimethylsilyl)methyl- substituted aryl derivatives
Werner, Veronika,Klatt, Thomas,Fujii, Masaya,Markiewicz, Jenifer,Apeloig, Yitzhak,Knochel, Paul
, p. 8338 - 8342 (2014/07/08)
A range of bis(trimethylsilyl)methyl-substituted aryl derivatives was prepared by using a Kumada-Corriu cross-coupling reaction. The regioselective metalation of the resulting bis(trimethylsilyl)methyl-substituted aryl derivatives bearing this bulky silyl group allowed the generation of functionalized aromatics. A regioselective switch in the presence or in the absence of the bis(trimethylsilyl)methyl group has been demonstrated. Furthermore, this silyl group was converted into a formyl group or a styryl group, enhancing the scope of application of such bis(trimethylsilyl)methyl- substituted arenes.
