1644246-65-0Relevant academic research and scientific papers
Gold-catalyzed direct hydrogenative coupling of nitroarenes to synthesize aromatic azo compounds
Liu, Xiang,Li, Hai-Qian,Ye, Sen,Liu, Yong-Mei,He, He-Yong,Cao, Yong
, p. 7624 - 7628 (2014)
The azo linkage is a prominent chemical motif which has found numerous applications in materials science, pharmaceuticals, and agrochemicals. Described herein is a sustainable heterogeneous-gold-catalyzed synthesis of azo arenes. Available nitroarenes are deoxygenated and linked selectively by the formation of N-N bonds using molecular H2 without any external additives. As a result of a unique and remarkable synergy between the metal and support, a facile surface-mediated condensation of nitroso and hydroxylamine intermediates is enabled, and the desired transformation proceeds in a highly selective manner under mild reaction conditions. The protocol tolerates a large variety of functional groups and offers a general and versatile method for the environmentally friendly synthesis of symmetric or asymmetric aromatic azo compounds.
